PubMed Publications: for sibley + LD                             

Alaganan A, Fentress SJ, Tang K, Wang Q, Sibley LD: Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1126-31. PMID: 24390541

Skillman KM, Ma C, Fremont DH, Cooper JA, Sept D, Sibley LD: The unusual dynamics of Toxoplasma actin result from isodesmic polymerization.  Nat. Comm. 2013, 4:2285. PMID: 23921463.

Sibley LD: The roles of intramembrane proteases in protozoan parasites.  BBA Biomembranes 2013, 1828; 2908-2915. PMID: 24099008.

Selleck EM, Fentress SJ, Beatty WL, Degrandi D, Pfeffer K, Virgin HW, MackMicking JD, and Sibley LD: Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii PloS. P., 2013 e1003320. PMID: 23633952.

Lourido S, Zhang C, Lopez M, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, and LD Sibley.  Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J. Med. Chem. 2013 56:3068-77. PMID: 23470217.

Lourido S, Jeschke GR, Turk BE, and LD Sibley: Exploiting the unique ATP-binding pocket of Toxoplasma calcium-dependent protein kinase 1 to identify its substrates. ACS Chem. Biol. 2013,8:1155-1162.  PMID: 23530747

Shen B, and Sibley LD: The moving junction, a key portal to host cell invasion by apicomplexan parasites.  Curr. Opin. Micro. 2012, 15, 449-455. PMID: 22445360.

Hunter C, Sibley LD: Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat, Rev Microb. 2012, 10(11):766-78. PMID: 23070557.

Behnke MS, Fentress SJ, Mashayekhi M, Virgin HW, Sibley LD: The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.  Plos P., 2012, 8(11): e1002992. PMID: 23144612.

Lourido S, Tang K, Sibley LD: Distinct signaling pathways control Toxoplasma egress and host-cell invasion. EMBOJ, 2012 31, 4514-4534. PMID: 23149386.

Su CL, Khan A, Zhou P, Majumdar D, Ajzenberg D, Dardé ML, Zhu XQ, Ajioka JW, Rosenthal B, Dubey JP Sibley LD: Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages. Proc. Natl. Acad. Sci. (USA), 2012, 109:5844-9. PMID: 22431627.

Sibley LD: Invasion and intracellular survival by protozoan parasites. Immunol. Rev. 2011, 240, 72-91. PMID: 21349087.

Khan A, Miller N, Roos DS, Dubey JP, Ajzenberg D, Darde ML, Ajioka JW, Rosenthal B, Sibley LD: A monomorphic haplotype of chromosome Ia is associated with widespread success of clonal and nonclonal populations of Toxoplasma gondii. mBio, 2011, 2:e00228-11. PMID: 22068979.

Skillman KM, Diraviyam K, Khan A, Tang K, Sept D, Sibley LD: Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites.  PLoS Pathogens, 2011, 7(10): e1002280. PMID: 21998582.

Mashayekhi M, Sandau MM, Dunay IR, Fickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM: CD8 alpha dendritic cells are the critical source of IL-12 controlling acute infection by Toxoplasma gondii tachyzoites.  Immunity, 2011, 35, 249-259. PMID: 21867928.

Mehta S, Sibley LD: Actin Depolymerizing Factor controls actin turnover and gliding motility in Toxoplasma gondiiMolec. Biol. Cell, 2011, 22, 1290-1299. PMID: 21346192.

Behnke MS, Khan A, Wootton JC, Dubey JP, Tang K, Sibley LD: Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9631-6. PMID: 21586633

Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD: Phosphorylation of immunity-related GTPases by a parasite secretory kinase promotes macrophage survival and virulence. Cell Host Microbe, 2010, 16;8(6):484-95. PMID: 21147463.

Steinfeldt T, Konen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC: Phosphorylation of IRG resistance proteins is an evasion strategy for virulent ToxoplasmaPLoS Biol, 2010, 8(12):e1000576. PMID: 21203588.

Dunay I, Sibley LD: Monocytes mediate mucosal immunity to Toxoplasma gondii.  Curr. Opin. Immunol. 2010, 22, 461-466. PMID: 20537517.

Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, and Sibley LD: Calcium dependent kinase 1 is an essential regulator of microneme secretion in Toxoplasma gondiiNature, 2010, 465, 359-362. PMID: 20485436.

Bugaliskis J, Brossier F, and Sibley LD:  Shedding of surface adhesins by rhomboid 4 is required for efficient invasion of Toxoplasma gondiiPLoS Path., 2010,6(4), e1000858. PMID: 20421941.

Metha S, and Sibley LD:  Toxoplasma gondii  actin deploymerizing factor acts primarily to sequester G actin.  J. Biol. Chem., 2010, 285, 6835-6847. PMID: 20042603.

Wernimont AK, Artz, JD,  Finerty P, Lin Y, Amani M, Allali-Hassani A, Vedadi M, Tempel W, Mackenzie F, Lourido S, Sibley LD, Hui R: Structural analysis of calcium-dependent protein kinases reveals a new twist in calcium sensing.  Nature Struct. Molec. Biol., 2010, 17, 596-601. PMID: 20436473.

Qiu W, Wernimont A, Taylor S, Tang K, Schapira M, Fentress S, Hui R, and Sibley LD: Structural and functional insights into a novel family of secretory serine-threonine kinases in Toxoplasma gondii. EMBO J., 2009, 28, 969-979. PMID: 19197235.

Starnes GL, Coincon M, Sygusch J, and Sibley LD: Aldolase is essential for energy production and bridging adhesin-cytoskeletal interactions during parasite invasion of host cells.  Cell Host Microbe, 2009, 5, 353-364. PMID:

Billker O, Lourido S, and Sibley LD: Calcium-dependent signaling and kinases in apicomplexan parasites.  Cell Host Microbe, 2009, 5, 612-622. PMID: 19527888.

Khan A, Taylor S, Ajioka JW, Rosenthal BM, and Sibley LD: Selection at a single locus leads to widespread expansion of virulence in Toxoplasma gondii.  PLoS Genetics, 2009, 5, e1000404. PMID: 19266027.

Dunay IR, Damatta RA, Fux B, Presti R, Greco SE, Collona M, and Sibley LD: Gr1+ (Ly6C+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondiiImmunity, 2008, 29, 306-317. PMID: 18691912.

Zhao Z, Fux B, Strong D, Miller BC, Cadwell K, Delgado M, Pnopuak M, Gren KG, Schidt RE, Mizushima N, Deretic V, Sibley LD, and Virgin HW: The autophagy gene ATG5 is essential for cellular immunity to intracellular pathogens.  Cell Host Microbe, 2008, 4, 458-469. PMID: 18996346.

Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN, and Sibley LD: Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondiiNature, 2008, 451, 207-210. PMID: 18185591.

Sibley LD, Ajioka JW: Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu Rev Microbiol. 2008;62:329-51. PMID: 18544039

Khan A, Fux BF, Su C, Dubey JP, Darde ML, Ajioka JW, Rosenthal BM, Sibley LD: Recent transcontinental sweep of Toxoplasma gondii driven by a single, monomorphic chromosome. Proc, Nat. Acad. Sci. (USA), 2007,104, 14872-14877. PMID: 17804804.

Saeij JPJ, Boyle JP, Coller SC, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, and Boothroyd JC: Polymorphic secreted kinases are key virulence factors in toxoplasmosis.  Science, 2006, 314, 1780-1783. PMID: 17170306.

Taylor A, Barragan A, Su C, Fux B, Fentress SF, Tang K, Beatty WL, El Hajj H, Jerome M, Behnke MS, White M, Wootton JC, and Sibley LD: A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii  Science, 2006, 314, 1776-1780. PMID: 17170305.

Starnes GL, Jewett TJ, Carruthers VB, Sibley LD.  Two separate, conserved acidic amino acid domains within the Toxoplasma gondii microneme protein 2 cytoplasmic tail are required for parasite survival.  J. Biol. Chem. 2006 PMID: 16923803

Khan A, Bohme U, Kelly KA, Adlem E, Brooks K, Simmonds M, Mungall K, Quail MA, Arrowsmith C, Chillingworth T, Churcher C, Harris D, Collins M, Fosker N, Fraser A, Hance Z, Jagels K, Moule S, Murphy L, O'Neil S, Rajandream MA, Saunders D, Seeger K, Whitehead S, Mayr T, Xuan X, Watanabe J, Suzuki Y, Wakaguri H, Sugano S, Sugimoto C, Paulsen I, Mackey AJ, Roos DS, Hall N,
Berriman M, Barrell B, Sibley LD, Ajioka JW.  Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii. Genome Res. 2006 16:1119-25. PMID: 16902086 
Supplemental files: ChrmIa.pdf

Boyle JP, Rajasekar B, Saeij JP, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC.  Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen likeToxoplasma gondii.  Proc. Natl. Acad. Sci. (USA). 2006 103:10514-9. PMID: 16801557

Nagamune K, Sibley LD.  Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa. Mol. Bio.l Evol. 2006 23:1613-27. PMID: 16751258
Supplemental files: CaBinding.aln  CDPK.aln  PATPase.aln VGCC.aln

Khan A, Jordan C, Muccioli C, Vallochi AL, Rizzo LV, Belfort R Jr, Vitor RW, Silveira C, Sibley LD.  Genetic divergence of oxoplasma gondii strains associated with ocular toxoplasmosis, Brazil.  Emerg. Infect. Dis. 2006 12:942-9. PMID: 16707050

Gordon JL, Sibley LD.  Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites. BMC Genomics. 2005 Dec 12;6(1):179 PMID: 16343347
Supplemental files: 092105ArpSuperfamily.aln

SahooN, Beatty W, Heuser J, Sept D, Sibley LD. Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasiteToxoplasma gondii, Mol Biol Cell. 2005, Nov 30,  PMID: 16319175

Wetzel DM, Schmidt J, Kuhlenschmidt MS, Dubey JP, Sibley LD. Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites.  Infect Immun. 2005, 73,5379-87.  PMID: 16113253

Chini EN, Nagamune K, Wetzel DM, Sibley LD. Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion inToxoplasma gondii Biochem J., 2005, 389, 269-77.PMID: 15773818


Robben PM, Laregina M, Kuziel WA, Sibley LD. Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis. J Exp Med. 2005 Jun 6;201(11):1761-9. Epub 2005 May 31. PMID: 15928200


Khan A, Taylor S, Su C, Mackey AJ, Boyle J, Cole R, Glover D, Tang K, Paulsen IT, Berriman M, Boothroyd JC, Pfefferkorn ER, Dubey JP, Ajioka JW, Roos DS, Wootton JC, Sibley LD. Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii. Nucleic Acids Res. 2005, 33(9):2980-92. PMID: 15911631
Supplemental files: 15911631.pdf


Barragan A, Brossier F, Sibley LD. Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2. Cell Microbiol. 2005, 7(4):561-8. PMID: 15760456


Brossier F, Jewett TJ, Sibley LD, and Urban S:  A spatially-localized rhomboid protease cleaves cell surface adhesions essential for invasion by Toxoplasma.  Proc. Natl. Acad. Sci. (USA), 2005, 102, 4146-4151. PMID: 1575328


Charron AJ, Sibley LD: Molecular partitioning during host cell penetration by Toxoplasma gondii.  Traffic, 2004,5, 865-867. PMID: 15479452

Wetzel DM, Chen LA, Ruiz FA, Moreno SNJ, Sibley LD: Calcium-mediated protein secretion potentiates motility  byToxoplasma gondiiJ. Cell Sci., 2004, 117, 5739-5748. PMID: 15507483

Sibley LD: Intracellular Parasite Invasion Strategies.  Science, 2004, 304, 248-253. PMID: 15073368
Supplemental files: 15073368SOM.pdf

Jewett TJ and Sibley, LD:  The Toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for intracellular survival. J. Biol. Chem. 2004, 279, 9362-9369. PMID: 14670959

Morrissette NS, Das A, Sept D, Sibley LD: Dinitroanilines bind alpha-tubulin to disrupt microtubules.  Molec. Biol. Cell, 2004, 15, 1960-1968. PMID: 14742718

Robben PM, Mordue DG, Truscott SM, Takeda K, Akira S, Sibley LD: Induction of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype. J. Immunol., 2004, 172, 3686-3694. PMID: 15004172

Su CL, Evans D, Cole RH, Kissinger JC, Ajioka JW, LD Sibley Enhanced oral transmission acquired through recent recombination led to widespread expansion of Toxoplasma.  Science, 2003, 299: 414-416.   PMID: 12532022
Supplemental files: 125320022SOM.pdf

Li L, Brunck B, Kissinger J, Pape D, Martin J, Wylie T, Dante M, Tang K, Cole R, Fogarty S, Howe D, Liberator P, Diaz C, White M, Jerome ME, Johnson EA, Radke JA, Haywood RE, Chakrabarti D, Waterston R, Clifton S, Roos D, LD Sibley Comparative gene expression in the Apicomplexa revealed by EST sequence analyses. Gen. Res., 2003, 13: 443-454. PMID: 12618375

Jewett TJ, and LD Sibley  Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites.  Molec. Cell, 2003, 11: 885-894. PMID: 12718875

Brossier F, Jewett TJ, Lovett JL, and LD Sibley  C-terminal processing of TgMIC2 is essential for invasion of host cell by Toxoplasma gondii. J. Biol. Chem., 2003, 278: 6229-6234. PMID: 12471033

Wetzel D, Håkansson S, LD Sibley  Actin filament polymerization regulates gliding motility by apicomplexan parasites. Molec. Biol. Cell. 2003, 14, 396-406. PMID: 12589042

Su CL, Howe DK, Dubey JP, Ajioka J, LD Sibley Acute Virulence in Toxoplasma is Mediated by Several Discrete Loci Common to the Type I Lineage. Proc. Natl. Acad. Sci. USA, 2002, 99: 10753-10758. PMID: 12149482
Supplemental files: 12149482SOM.pdf

Barragan A, Sibley LD: Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence.  J. Exp. Med., 2002,195: 1625-1633. PMID: 12070289

Lovett Jl, Moreno SNJ, LD Sibley Toxoplasma gondii microneme secretion involves intracellular Ca+2 release from IP3/ryanodine sensitive stores. J. Biol. Chem., 2002, 277: 25870-25876. PMID: 12011085

Mercier C, Dubremetz JF, Rauscher B, Lecordier L, LD Sibley, Cesbron-Delauw MF, Biogenesis of a nanotubular network in the Toxoplasma parasitophorous vacuole induced by parasite proteins. Molec. Biol. Cell, 2002, 13:2397-2409. PMID: 12134078

Mordue DM, Monroy F, La Regina M, Dinarello C, LD Sibley Acute toxoplasmosis leads to lethal over-production   of Th1 cytokines. J. Immunol. 2001, 167: 4574-4584. PMID: 11591786

Håkansson S, Charron AJ, LD Sibley  2001 Toxoplasma evacuoles: a two step process of secretion and fusion   forms the parasitophorous vacuole.  EMBO J. 20: 1-13. PMID: 11406590

Carruthers VB, Sherman GD, LD Sibley 2000 The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two distinct parasite-derived proteases.  J. Biol. Chem. 275, 14346-14353.  PMID: 10799515

Mordue D, Desai N, Dustin M, LD Sibley 1999 Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring. J. Exp. Med. 190, 1783-1792. PMID: 10601353

Håkansson S, Morisaki H, Heuser JE, LD Sibley 1999 Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion.  Molec. Biol. Cell, 10:3539-3547. PMID: 10564254

Mordue D, and LD Sibley 1997 Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanism of entry. J. Immunol. 159: 4452-4459. PMID: 9379044

Dobrowolski J, and LD Sibley. 1996 Toxoplasma invasion of mammalian cells is powered by the parasite's actin cytoskeleton. Cell  84: 933-939. PMID: 8601316

Sibley LD, M Messina, and IR Niesman. 1994 Stable transformation in the obligate intracellular parasite Toxoplasma gondii by complementation of tryptophan auxotrophy.  Proc. Natl. Acad. Sci. (USA) 91:5508-5512. PMID: 8522178

Sibley LD, and JC Boothroyd.  1992.  Virulent strains of Toxoplasma gondii  comprise a single clonal lineage. Nature (Lond.) 359: 82-85. PMID: 1355855

Sibley LD, Krahenbuhl,JL, Adams GMW, and E Weidner. 1986.  Toxoplasma  modifies macrophage phagosomes by secretion of a vesicular network rich in surface proteins. J. Cell Biol. 103: 867-874. PMID: 3528173

Sibley LD, Weidner E, and JL Krahenbuhl. 1985.  Phagosome acidification blocked by intracellular Toxoplasma gondii.  Nature (Lond.) 315: 416-419. PMID: 2860567