CLUSTAL X (1.81) multiple sequence alignment


HsCAC1B         ------------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          MGGGELVNCIAYDDNTLVIERKPSPSSPSTSRRYLKAETPTRGSRKYNRKSSAKSDLEVV
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         ------------------------------------------------------------
MmCACNA1A       ------------------------------------------------------------
CeCCA1          ----------------------------------------------------------ML
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         --MIYDSIQINPEDKKQNSNIANDQTKNNQTENGTKISSQPNNLNQSTLITSNQVIRNDN
Tt8511          ------------------------------------------------------MLSSSS
Tt8517          -----------------------------------------------MSFYLLFIQLKNI
Tt8516          ----------------------------------------------MTQFNSIRIKNKNQ
Tt11012         ------------------------------------------MKQSTENNQNDEHGQQIQ
Tt27559         --------------------------------------------------MNTYVEQYTD
Tt14193         ----------------------------------------------------------MD
Tt27255         ------------------------------------------------------------
ScCCH1          -----------------------------------MQGRKRTLTEPFEPNTNPFGDNAAV
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ----------------MVRFGDELGGRYGGPGGGERARGGG-------------------
CeEGL19         ----------------MSVLASMMS-------SGEDEEQAA-------------------
CeUNC2          ----------MIPIAASEIIPSPIHPRKISINDRLFEIRTP-------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          VVKPEHHHQHRSPTITLPVPANPLTTSASAGSSPTGAGLAAGLGTASGTVLQQSCSALDP
MmCACNA1D       --------------MNLPTFSSDLILIKSVLSQETDARYKG-----------RVVSAVES
RnCAC1B         ----------------MVRFGDELGGRYGGTGGGERARGGG-------------------
MmCACNA1A       ----------------MARFGDEMPGRYGAGGGGSGPAAGVVVG----------------
CeCCA1          RQPVPELRSFQSLSKYAGGPRSVLGRRTSAITVNRRQSQSTRRHE---------------
MmCACNA1H       ---------MTEGTLAADEVRVPLGASPSAPAAPVRASPASP------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         HPNKQEYFDDKRHNSNHNQIDSKFDNQRYNSDERECNNLEKHSKDQEGIDKQNIYIKEQK
Tt8511          QNKQGYWIEKLKEILKEEKIEEEESSQFNNSSDGNIQNQNSGIKTQESMPGSANSQNEIS
Tt8517          XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFQKQFEIQIKLQDFKNKIITVLILSF
Tt8516          RNQICQQQNEFIRCRLRQVLKQEIPEETEEDKTFKRIEKAKAGKEKKSQIDNFNNKNQDI
Tt11012         IRNDVKITKNIESSKWIQKLKTIFENELPSSSKKKQKIKDKKVILQTQDSQTDDYEENSD
Tt27559         TVNYRRGGLFKYPTKGSATLRTQYSLQTRKKKGLIPKKIPEKFTQREYDNNELSSKWDVK
Tt14193         ASLTGNVKSPHVQFDSLNQMSPHFNQQGGIIEALKNNANFTKRNNEDLDDDYLSFLSSNG
Tt27255         ------------------------------------------------------------
ScCCH1          MTENVEDNSETDGNRLESKPQALVPPALNIVPPESSIHSTEEKKGDEYNGNDKDSSLISN
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ------------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          PEDSNQPSGTRRRPTSTELALSNVTSQIVNNATYKLDFKQRRHKSNNGGSESGSLTGIAT
MmCACNA1D       TEDFSQAFAEANYARGTRLPIS--------------------------------------
RnCAC1B         ------------------------------------------------------------
MmCACNA1A       ------------------------------------------------------------
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         SQNSTQRSNIQGLNQDMRQETYEQASSNKNLELEKTNRSQSKIMESIGLDSNRNNSSSNQ
Tt8511          FLENDNKQGKKEQNKIMYQKVAEAFYK---------------------------------
Tt8517          NQDGKKCQSIQIYTFGDYIVIFQYTYFTQITQLPLCDLQFQVVFLADSGSFLQKKNIYFN
Tt8516          SDDSSNSSSSFDLNNLVEENVAN-------------------------------------
Tt11012         DVNSQDMSFLQNKKDKKKIAAEMN------------------------------------
Tt27559         NKALLEYTSINEE-----------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          IFRTRVGRSSHENLSRPKLSLKTASFGAAESSRRNVSPSTKSAKSSSQYIDLNDERLRRR
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ------------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          GPATSPAGPTGPTSSSGKRRKSSCTSCGGGGISAPPPRLTPEEAWQLQPQNSVTSAGSTN
MmCACNA1D       -----GEGPTSQPNSSKQTVLS--------------------------------------
RnCAC1B         ------------------------------------------------------------
MmCACNA1A       ------------------------------------------------------------
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         FNRLTSNNNIQTNRNYDDSQNEENFNTGRSKNTENFSSKLEVELKQLNKGKKKQSKRDSL
Tt8511          ------------------------------------------------------------
Tt8517          FKKIILFQKVLVKIYLQINNNILEANWIRKLKKILKTEIKEEAIEEDQLSRYSKFQQNEE
Tt8516          ------------------------------------------------------------
Tt11012         ------------------------------------------------------------
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          SFSSYSRSSSRRVSNSPSSTDRPPRSAKVLSLIAADDMDDFEDLQKGFKSAIDEEGLTWL
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ------------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          SSFSSGGGRDDNSSYSAVGGDSSSSNSCNCDITGDNSTLHGFGVGDVCSFIADCDDNSED
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         ------------------------------------------------------------
MmCACNA1A       ------------------------------------------------------------
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         GLSAQEKALIEKMKLNTNQRNSQKSPLRNLIGKQIYEDQLGKTTKNNREEQNGTPQKRLS
Tt8511          ------------------------------------------------------------
Tt8517          LKRQRSESYQDYTSQDMNESSSFDLKN-----------------------------LQEE
Tt8516          ------------------------------------------------------------
Tt11012         ------------------------------------------------------------
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          PQLKSEKSRPVSDVGEDRGEGEQESIPDVHTPNVGASATPGSIHLTPEPAQNGSVSEGLE
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         -------------------AGGAGGPGPGGLQPGQRVLYKQSIAQRARTM----------
CeEGL19         -------------------ADEQERTDLWQQTLQAAVAASSSQDATKKRP----------
CeUNC2          -------------------RPGEMIKEAVQMAVWPALPRLAAEEARREQK----------
DmCA1A          ------------------------------------------------------------
DmCA1D          DDGDPNNQDLSSQTLRTAAIVAAVAAAAKEQAQEQSLADCESFSDRRQDADEDVRIIQDC
MmCACNA1D       ---------------WQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQ----------
RnCAC1B         -------------------AGGAGGPGQGGLPPGQRVLYKQSIAQRARTM----------
MmCACNA1A       -----------------AAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTM----------
CeCCA1          ---------------DVEALGSIEGSKETLQLSEHGRLASSSEASPSR------------
MmCACNA1H       ---------------------GVPG-------REEQRGSGSSVLAP--------------
CeNCA1          -----------MSERKKSLITTINNQRKYSQVAKAAVLSSAMLARKNSSS----------
RnRB21          -----------------------------------------MLKRKQSS-----------
CeNCA2          -------------------MTSTTAKLLGLSACRAAALSTTMLTRRKSSI----------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         KIRYSNNSVTPIQMVNSPGQNASQRIQYKTPNQKSFNLEDSQISEQDKSIKSEIRNLRQR
Tt8511          ------------EQSFIIDNDENEEQDKQIQKLKQEVEEQQSFFDSEDEFDKAYNDQKN-
Tt8517          AEEHRNAYIKVANAFVEQNSDDSDNDIARANETDQQRIQRKVIKNHEREFEEDFQLNKLN
Tt8516          -------------AFLEQDSDKSDNEIQKLNKENEQRLQKKIENHYEQEFETEFQINKLS
Tt11012         --------------QKDDGNNHDEEDLWDWMRNQNKYEEKDSDEQLIHSFQEQE------
Tt27559         ---------------RHYAVGEERKMVDKSTFQGLNSFQMKSLFFQKDED----------
Tt14193         ---------------RINFQSQISELKSDINIPQTQGFFSKTRQKQQPSICEEQE-----
Tt27255         ------------------MNQTPQKANNQETIAINNILSSPQYIQQNVQID---------
ScCCH1          GSINNSRKKPSPKFFHHLSPQKEDKDQTEVIEYAEDILDFETLQRKLESRPFVLYGHSLG
20.m03897       ----------------MICIYAYEEILRFFSCGSTRDYARKSYNVFNPNN----------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ------------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          CGGNNDSLEDVGEVDDNADVVVRKNSRNRPSIRRTCRITEEDDDEDENADYGDFDREDQE
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         ------------------------------------------------------------
MmCACNA1A       ------------------------------------------------------------
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         LNSKQQTSQDSQSDASSSERERSLDKNYIYNEQDEVEEEYNTRGVQGKMYQKVRDLLQQQ
Tt8511          ------------------------------------------------------------
Tt8517          ------------------------------------------------------------
Tt8516          ID----------------------------------------------------------
Tt11012         ------------------------------------------------------------
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          VFSPTN------------------------------------------------------
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ------------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          LDDEEPEGTTIDIDEQEQQHDQGDSAEEEDDDEDVDEYFEEEEDDTQAFSPFYSSSAELI
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         ------------------------------------------------------------
MmCACNA1A       ------------------------------------------------------------
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         LDEDGGQNQEDEEDELNQHEQQIIVPEDFIDQNTLDEYEKLTQEQEVRTQN---------
Tt8511          ------------------------------------------------------------
Tt8517          ------------------------------------------------------------
Tt8516          ------------------------------------------------------------
Tt11012         ------------------------------------------------------------
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ------------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          DNFGGGAGKFFNIMDFERGASGEGGFSPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMG
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         ------------------------------------------------------------
MmCACNA1A       ------------------------------------------------------------
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ------------------------------------------------------------
Tt8511          ------------------------------------------------------------
Tt8517          ------------------------------------------------------------
Tt8516          ------------------------------------------------------------
Tt11012         ------------------------------------------------------------
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         -----------------------------ALYNPIPVKQNCFTVN-------RSLFVFSE
CeEGL19         -----------------------------AQRKPLRQTNVVERSE-------RSLLCLSL
CeUNC2          -----------------------------AESGTFVRKTTLSSNAPVKEKGPSSLFIFAE
DmCA1A          ---------------------------------MGGPKKEEN----PPGGGPTSLFILTE
DmCA1D          IDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRGKPQPDRPQRALFCLSV
MmCACNA1D       ---------------------------------YAKSKKQGN---SSNSRPARALFCLSL
RnCAC1B         -----------------------------ALYNPIPVKQNCFTVN-------RSLFVFSE
MmCACNA1A       -----------------------------ALYNPIPVRQNCLTVN-------RSLFLFSE
CeCCA1          -------------------------WEGRQIEWGNEEQIEEESELPYPGFAEPALRCFYQ
MmCACNA1H       --------------------------ESPGTECGADLGADEEQPVPYPALAATVFFCLGQ
CeNCA1          ----------------------------------RGAPGSAAGFGARESIAAISDMLSSQ
RnRB21          ----------------------------------RVEAQPVTDFGPDESLSDNADIL---
CeNCA2          ----------------------------------DGTKTERNRRRGESIGGAFTDMINIE
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         -----------------------QYLKTYKVQKKSALDKLGYLFYRPSIFLQVFKFFFYL
Tt8511          --------------------------KAFLDIVEMNDFDRINQYQDHTIFQKIYKKIWYT
Tt8517          -----------------------EDTYPILDVVEMNVFDRIAIFQDNTIFEKIYKRVWLT
Tt8516          -------------------------NNPVLDVVEMNVFDRIALFQAVTIFEKIYKQVWYI
Tt11012         --------------------------AEFLALKEKEEQNKFLDIVEMNEYQKIQKFNADT
Tt27559         -----------------------------LEEDNSKKMVQFFYHGKTFTYCKESCQLFKK
Tt14193         -------------------------FESTKKVSKQNTLPANTKLNEQNDNKEKIKNNKQQ
Tt27255         -----------------------------QLQNEKNITRNSQEGIISKKIQDANNEIDRN
ScCCH1          -------------------------PLRIKIARFLLHRRYSLLYNTLLTFYAILLAIRTY
20.m03897       -----------------------------RFRRICTLLKGSTTLKYLLITYACTNELVHL
583.m05406      ------------------------------MALNNGSLSSSLASPPPFASSALSPSSLSC
Tg3277          --------------------------MKWKVSRGTVRLRGVHFALPSAENLTEAALYWRS
                                                                            

HsCAC1B         DNVVRKYAKRITEWPPFEYMILATIIA-----NCIVLALEQH---LPD--GDKTPMSERL
CeEGL19         NNPIRKLCISIVEWKPFEFLILFMICA-----NCIALAIYQP---YPA--QDSDYKNTLL
CeUNC2          DNIIRRNAKAIIEWGPFEYFILLTIIG-----NCVVLSMEQH---LPK--NDKKALSEWL
DmCA1A          DNPIRKYTRFIIEWPPFEYAVLLTIIA-----NCVVLALEEH---LPG--GDKTVLAQKL
DmCA1D          KNPLRALCIRIVEWKPFEFLILLTIFA-----NCIALAVYTP---YPG--SDSNVTNQTL
MmCACNA1D       NNPIRRACISIVEWKPFDIFILLAIFA-----NCVALAIYIP---FPE--DDSNSTNHNL
RnCAC1B         DNVVRKYAKRITEWPPFEYMILATIIA-----NCIVLALEQH---LPD--GDKTPMSERL
MmCACNA1A       DNVVRKYAKKITEWPPFEYMILATIIA-----NCIVLALEQH---LPD--DDKTPMSERL
CeCCA1          ARPPRKWALQMVMSPWFDRITMAVIMI-----NCVTLGMYRP---CEDGPDCDTYRCQIL
MmCACNA1H       TTRPRSWCLRLVCNPWFEHISMLVIML-----NCVTLGMFRP---CED-VECRSERCSIL
CeNCA1          HKKPV--RSSYVESDRVEWALKIACTI-----SMITVCIHTP---RTI--ELFQPLNYII
RnRB21          ----------WINKPWVHSLLRICAII-----SVISVCMNTP---MTF--EHYPPLQYVT
CeNCA2          PTSIINKSTELLHERFLRDMVRVACLL-----SMISLCLHTP---ETI--KMWPPLNYII
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         -------------MPGPCREFLPQQVR-----EGPGICLLTS---APELPTPPTRLFNKA
HsTPCN2         ------------------------------------------------------------
Tt10302         KCAISDFCYKIIKSNWFENTILLIIIF-----NSIMLMLDDP---TTD------VQSSFA
Tt8511          KVLINWIALKIINHPVFEVISLGVIIF-----NSILLSLDDP---TTN--------SDNN
Tt8517          KELISYSCFVIVNHPIFTIISLAVIIF-----NSIMLAKDDP---TTN--------SDNN
Tt8516          KEKISYICFCIINHNIFTVISLSVIIF-----NSVMLARDDP---TTN--------SDNN
Tt11012         LPRKIFKQIWSIKNKPFEYATLCVILF-----NCVILAMDDP---TTN------ADDQQR
Tt27559         EHLIRRLSVWITEWNYYKFFTFITILT-----MAVFMGMHNYNL-SDEENIKQGGYQSIF
Tt14193         RRSLFVPNSSDIDIEDHNQVVLRSTIR-----KLTQRGVVLKDQ-KEQNTINEIKDKEES
Tt27255         TQNYLQTHEEQDQQQTFRWIIIASTLA-----EIAAYLMHDYSYRITKQRKESLQINVVA
ScCCH1          NPHNVVFLYRFSNWTDYFIFILSACFTGNDIAKIIAFGFWDDSEMFKAYGREYKSILQRS
20.m03897       EAMASRIPLRFAELLDIILVILLLLEFVYETVAIGLWKGRKCYFRQPCCLFNFAILAVAI
583.m05406      SSPSSSSSSSSSSSSSSSSSSRRAENG-----LSSMLSRTPPSPSQERQGSPDASLCASV
Tg3277          RAGRLGSVVEGLDGPAKSGLALSWRLPR----SRRIRNLTMEGRETSAGRPLSSRLLQLA
                                                                            

HsCAC1B         DDTEPYFIG-------IFCFEAGIKIIALGFVFHKG------------------------
CeEGL19         ETIEYVFIV-------VFTIECVLKIVAMGFMFHPS------------------------
CeUNC2          ERTEPYFMG-------IFCLECVLKVIAFGFALHKG------------------------
DmCA1A          EKTEAYFLC-------IFCVEASLKILALGLVLHKH------------------------
DmCA1D          EKVEYVFLV-------IFTAECVMKILAYGFVLHNG------------------------
MmCACNA1D       EKVEYAFLI-------IFTVETFLKIIAYGLLLHPN------------------------
RnCAC1B         DDTEPYFIG-------IFCFEAGIKIIALGFVFHKG------------------------
MmCACNA1A       DDTEPYFIG-------IFCFEAGIKIVALGFAFHKG------------------------
CeCCA1          DIIDNCIFV-------YFAFEMVIKIMALG-FYGPA------------------------
MmCACNA1H       EAFDDFIFA-------FFAVEMVIKMVALG-LFGQK------------------------
CeNCA1          LAADFISVS-------IFMLDSVLRIHYEGIFRCDS------------------------
RnRB21          FTLDTLLMF-------LYTAEMIAKMHIRGIVKGDS------------------------
CeNCA2          LANDVIVTL-------IFIGEAAVTINQNGLFDNQN------------------------
NtTPC1A         ----------------------------------ME------------------------
AtTPC1          ----------------------------------ME------------------------
OsTPC1          -------------------------MRERGEMREAK------------------------
CfTPCN2         SSQPRRVLS-------ALPWSVWRRVPPRGRGPVSS------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         DWCEQFFLW-------AYTVEACLKIIALGFILPQG------------------------
Tt8511          AEMDQALLI-------IYTIEMGLKIIALGFIFNKG------------------------
Tt8517          PEIDLALLI-------IYTVEMGLKIVAYGFIFSKN------------------------
Tt8516          PAIDLSLLV-------IYTVEMGLKILAMGFIFSKN------------------------
Tt11012         LQIDLILLI-------LYTVEMGFKILALGFIFNKG------------------------
Tt27559         SYTKYFYIS-------YFAIEIVLKIIARGLYQSYN------------------------
Tt14193         PKNDDNFLF-------ATNLKDLIKLENGILEHEAF------------------------
Tt27255         DYFELITNI-------IFTIEIIFIIFAYGAHRKTL------------------------
ScCCH1          GIMKLYIYLREKYGRKLIDFIIPFRIISPGEETKYQRSSLSTSLTKPYGAKENQRPFGTP
20.m03897       SEVIVTYLARCHPPDYIPQVSWYTSEVALFFELVRKLR---------------------V
583.m05406      CSSFFSFAS-------SPPPSASSSLSSLPPALSSSG-----------------------
Tg3277          READEAEAAG------RLDLTSPLCAAASPDSLCGSD-----------------------
                                                                            

HsCAC1B         -SYLRNGWNVMDFVVVLTGIL-------ATAG------------TDFDLRTLRAVRVLRP
CeEGL19         -AYLRNAWNILDFIIVVIGLV-------STILS-------KMSIQGFDVKALRAFRVLRP
CeUNC2          -SYLRSGWNIMDFIVVVSGVVTMLPFSPATQTA-------NQPVDSVDLRTLRAVRVLRP
DmCA1A          -SYLRNIWNIMDFFVVVTGFMTQYP--QIGPE--------------VDLRTLRAIRVLRP
DmCA1D          -AYLRNGWNLLDFTIVVIGAISTALSQLMKDA--------------FDVKALRAFRVLRP
MmCACNA1D       -AYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGN--HSSGKSGGFDVKALRAFRVLRP
RnCAC1B         -SYLRNGWNVMDFVVVLTEILATAG-------------------TDFDLRTLRAVRVLRP
MmCACNA1A       -SYLRNGWNVMDFVVVLTGILATVG-------------------TEFDLRTLRAVRVLRP
CeCCA1          -AYMSDTWNRLDFFIVMAGIAEFVLHEYLG--------------GNINLTAIRTVRVLRP
MmCACNA1H       -CYLGDTWNRLDFFIVMAGMMEYSLDG-----------------HNVSLSAIRTVRVLRP
CeNCA1          -SYLSNRWSQFSVFISIIHLLSFLLHCYQLIDNFFPFLHLNYRAWYGAIRSIRPFIIIRL
RnRB21          -SYVKDRWCVFDGFMVFCLWVSLVLQVFEIAD------IVDQMSPWGMLRIPRPLIMIRA
CeNCA2          -SYLRDRWYQFEFFLLINHILSCVIHIYELCSIWFPALNFVYYPWLGALRSARPFIFLRF
NtTPC1A         -EYLLSG-----------------------------------------------------
AtTPC1          -DPLIGR-----------------------------------------------------
OsTPC1          -APLIAEA-------------------------------------AEHISHSHGSGSSGT
CfTPCN2         -APTRTLRSYWLVAKGIPDVT--------------------------ALSSPPPDLRRRG
HsTPCN2         ------------------------------------------------------------
Tt10302         -AYLKDGWNILDFAIVVSSLLPLVIG-----------------SSTVNLRALRSLRILRP
Tt8511          -AYLRDTWNIIDIVIIITGFLPQNE---------------------INLSALRSLRVLRP
Tt8517          -AYIKEGWNVIDLVIIVTGWLPYVVS-----------------QNAFNLSALRSLRVLRP
Tt8516          -SYLSEGWNVLDFVIIVTGWLPYVIN-----------------SSSFNLTALRSLRVLRP
Tt11012         -SYMRDMWNILDITIIITGYLPYVVN-----------------TSQVNLSAVRSLRVLRP
Tt27559         -SYLKNINNLIILIVFGIIVIYDTS--------------------FIFLFIFRIFYVFEF
Tt14193         -QIMKPIRLPFDKQKIEPKKLYKKTQTFQFPKFYS----------HKYFKLDEDSQQVKE
Tt27255         -NQIFTTLNALLLTVLISSWISYATD---------------------EIEVFNVYKHFRI
ScCCH1          RAFARSSWNRIDLVSSVSFWLGMFLSIKSYDT-------------KTGIRIFKPLAILRI
20.m03897       LRLFETKTCKLAFTIFRKCVANLLALAG-----------LVFIFVFFYLIVYFHTYGYTQ
583.m05406      -GDLRRAAACWVYSVSLLEQQPALPGG-----------------AFRTRRQQKAFCLFLR
Tg3277          -SRLLQAAGE-----------------------------------GDAAGPPASSGTVSP
                                                                            

HsCAC1B         LKLVSGIPSLQVVLKSIMK-AMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNST
CeEGL19         LRLVSGVPSLQVVLNAILR-AMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCIDPAT
CeUNC2          LKLVSGIPSLQVVLKSILC-AMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNERG
DmCA1A          LKLVSGIPSLQVVLKSIIK-AMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLED
DmCA1D          LRLVSGVPSLQVVLNSILK-AMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEIT
MmCACNA1D       LRLVSGVPSLQVVLNSIIK-AMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADS
RnCAC1B         LKLVSGIPSLQVVLKSIMK-AMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNST
MmCACNA1A       LKLVSGIPSLQVVLKSIMK-AMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGT
CeCCA1          LRAVNRIPSMRILVNLLLD-TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCVINLP
MmCACNA1H       LRAINRVPSMRILVTLLLD-TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA
CeNCA1          IPLVVKFKLPKNRIEQLLKRSSQQVKNVTLFFVFFMTLYAIFGIQLFG-RMDYHCVQPKT
RnRB21          FRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFG-TFTYHCVVNDT
CeNCA2          IRSIVRFKLPKNRIKLIIKRSSQQIQNVTIFFMFFVFSYAIMGVQLFG-RLNYHCVVNGT
NtTPC1A         --ESSNSGRTRRRIGSIFDRRDAIAHGSAYQKAAALVDLAEDGIGLPEEILEGASFEKAA
AtTPC1          --DSLGGGGTDR-----VRRSEAITHGTPFQRAAALVDLAEDGIGLPVEILDQSSFGESA
OsTPC1          GSHTSGGGGGWRGSRQYQRRSDALAYGNRYQKAAALVDLAEDGVGIPEDVLNDTRFERAM
CfTPCN2         RRACAVGSRAGSCSPGRVRRPLPMADPRAESEPLLGRARGGSGHDWPAGSAACGSVRGDP
HsTPCN2         -----------------------MAEPQAESEPLLGGARGG-GGDWPAGLTTYRSIQVGP
Tt10302         LRTISKVKKLKILLKTLFS-AIPYLVNSMIILTFFFLIFAIGGLQLFGGLLLRRCLDPLS
Tt8511          LKSITKIKALKQLIQALLS-SIPLLKDSIIILSFFFIIFGIAGLQLFTGQLKSRCIDPQL
Tt8517          LRSISKVKVLNQLVTALFS-SIPLLKDAFIILLFFFTVFAIAGLQLFTGQLKTRCIDIYT
Tt8516          LRSISKVKILNQLVTALFT-AIPLLKDAFIILCFFFGVFGIAGLQLFSGQLKTRCIDIYT
Tt11012         LRTISRIKALKQILNTLFS-SFSLLKDAIIIIIFFYLVFAIAGQQLFTGCLKKRCFDSSN
Tt27559         TSNIKQLR-KSYIILKLYQISGETLFKLLFLIFFFITLFGILSTNIFSGSLDYRCRTTPV
Tt14193         QPEESQKPPEQLHWKDNLKIFLKSKRYNTFFIALSLLNLLAFMVDDYSSRRPTGATENSN
Tt27255         LTIFRLFPVLAKKVNAFFG-SFKHLGKTFFPLICVIIFYSVIGISFFRGHIESRCRLTKH
ScCCH1          LRLVNVDTGMPSILRGLKY-GIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNP
20.m03897       FNVCHTQVTEKTQISQAASPSVTFSHDTADASLMCNAESGYWEYDLSQEYLCRPDLPCRD
583.m05406      LQPLVKLALCLYLLLAFFEDSDSSSALRKNARTSSALSATRHTISPSSPASQSRLDASPS
Tg3277          RSRALGNPIPFGDRQHARRLTSLPYRRTSSACLIPLLSSSAEGRTPWRGEETPEARGLVS
                                                                            

HsCAC1B         D-------------------AEPVGD--FPCG------KEAPARLCEG------------
CeEGL19         G-------------------QLAQKDP-TPCGTD----TEGSAFKCQPSDSLTNM-----
CeUNC2          E-------------------IENVSERPMPCTN-----KTSPMGVYNCDVK---------
DmCA1A          PNK-----------------LVKEGESETPCNTDNILEKATGSFVCNN------------
DmCA1D          G---------------------EYEENIRPCGVG---------YQCP-------------
MmCACNA1D       D--------------------IVAEEDPAPCAFSG------NGRQCTA------------
RnCAC1B         D---------------------AEPVGDFPCGKEAP------ARLCDS------------
MmCACNA1A       D--------------------DIQGESPAPCGTEEP------ARTCPN------------
CeCCA1          KTISENQSALFNNVKLTRFYIPEDTSLEYICSQPDA----NGLHTCSNLPPYTVDGVKCN
MmCACNA1H       FVRNNNLTFLR-----PYYQTEEGEENPFICSSRRD----NGMQKCSHIPSRRELRVQCT
CeNCA1          D-------------------PNNVTIMDLAIPDTMCAPEGIGGYECPAP-----------
RnRB21          K-------------------PGNVTWNSLAIPDTHCSPELEEGYQCPPG-----------
CeNCA2          D-------------------PNNVTIADLAIPDTMCSQKGAGGYECPGN-----------
NtTPC1A         E-----------------------------------------------------------
AtTPC1          R-----------------------------------------------------------
OsTPC1          R-----------------------------------------------------------
CfTPCN2         G-----------------------------------------------------------
HsTPCN2         G-----------------------------------------------------------
Tt10302         G---------------------IVADYNQVCGGG---------YQCDD------------
Tt8511          G-----------------IMEGDDGDNVIVCASDSDCANTP-------------------
Tt8517          G-----------------IKYGDENNNLFVCAVDSDCPPLKG------------------
Tt8516          G-----------------IKLGDENNNLFVCAQDGDCPIQQG------------------
Tt11012         G-----------------IQFGDNDQNVFLCIEDIDCYQYAESNSK--------------
Tt27559         PGQGDWELAQG---------VYRVCGGRFSCPDNTYCGSNYSYIKNDTSYIDS-------
Tt14193         LR------------------STFAETIQFSCSFIFVSDIILQIIYRGFWKQKN-------
Tt27255         PEEGE-------------TIWEIDESVHLPCGVASCPSQSYCGNPAEYG-----------
ScCCH1          EDP-----------------TDTYQYDMQFCGGYLDPVTKRKQNYIYEDGSEGSVSKG--
20.m03897       G---------------------TECRNIFTLPRESTLCSSSQIFKLQQK-----------
583.m05406      S-----------------------------------------------------------
Tg3277          VS----------------------------------------------------------
                                                                            

HsCAC1B         ---------------------------DTECREYWPGPNFGITNFDNILFAILTVFQCIT
CeEGL19         -----------------------GVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVS
CeUNC2          ---------------------------GTTCLQKWIGPNYGITSFDNIGFAMITVFQCIT
DmCA1A          --------------------------TTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCIT
DmCA1D          --------------------------PGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVT
MmCACNA1D       --------------------------NGTECRSGWVGPNGGITNFDNFAFAMLTVFQCIT
RnCAC1B         ---------------------------DTECREYWPGPNFGITNFDNILFAILTVFQCIT
MmCACNA1A       ---------------------------GTKCQPYWEGPNNGITQFDNILFAVLTVFQCIT
CeCCA1          LTLDEYDKVTN-------DSCINWNIYYNECQVMQRNPFQGSVSFDNIGFAWVAIFLVIS
MmCACNA1H       LGWEAYGQPQAEDGGAGRNACINWNQYYNVCRSGEFNPHNGAINFDNIGYAWIAIFQVIT
CeNCA1          ------------------------MVCMQLNLN--AKGEGFYGMFNDFGASVFTVYLAAS
RnRB21          ------------------------FKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEASS
CeNCA2          ------------------------MVCMRLQLK--PQEEGFYGQFSDFASSLFTVYLAAS
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ---------------------------IYICGKTMSNPQFNVTNFDDIFYSFLMVFQVIT
Tt8511          -------------------------EYSLICSKTMKSPFYDTIQFDTFGWSVLNVYVIVS
Tt8517          --------------------------ASFICAKGMVSPNSDFYNFDTFGWSLLNVYVVVS
Tt8516          --------------------------ISYICAKGMVSPNSDLYNFDTFGWSLLNVYVVVS
Tt11012         --------------------------IHYICGKGMVSPFWDTENFDTFGWALLNVYVVVS
Tt27559         --------------------------ANMDKPTSSRYYNYGITNFDNLYQTYLTLFLFYM
Tt14193         ----------------------AFFKNPWHLFNFFSVLSSVIVGFTGSLNAFSIILRVLG
Tt27255         -------------------------LPEYHHEFDNEHMLWGYVNFNDIFNALFSVYNFLM
ScCCH1          -----------------------FLCPQYSKCVSNANPYNGRISFDNIVNSMELVFVIMS
20.m03897       ---------------------------GWSSMYDTPLGDWGMTGFHNAFSALISFLQCVT
583.m05406      --------------------------LSFSSHASSSSSSSSSSSSSSSPSFAPPSSSSSL
Tg3277          -------------------------AHASGAQTRARESRVSSVASDCEEGEVSPLFSRRE
                                                                            

HsCAC1B         MEGWTDILYNTNDAAGNTWNWLYFIP---LIIIGSFFMLNLVLGVLSGEFAKERER----
CeEGL19         LEGWTDVMYWVNDAVGREWPWIYFVT---LVILGSFFVLNLVLGVLSGEFSKEREK----
CeUNC2          MEGWTTVMYYTNDSLGSTYNWAYFIP---LIVLGSFFMLNLVLGVLSGEFAKERER----
DmCA1A          MEGWTAILYWTNDALGSAFNWIYFVP---LIVIGSFFMLNLVLGVLSGEFSNERNR----
DmCA1D          LEGWTDVLYSIQDAMGSDWQWMYFIS---MVILGAFFVMNLILGVLSGEFSKERNK----
MmCACNA1D       MEGWTDVLYWVNDAIGWEWPWVYFVS---LIILGSFFVLNLVLGVLSGEFSKEREK----
RnCAC1B         MEGWTDILYNTNDAAGNTWNWLYFIP---LIIIGSFFMLNLVLGVLSGEFAKERER----
MmCACNA1A       MEGWTDLLYNSNDASGNTWNWLYFIP---LIIIGSFFMLNLVLGVLSGEFAKERER----
CeCCA1          LEGWTDIMYYVQDAHS-FWNWIYFVL---LIVIGAFFMINLCLVVIATQFAETKRRETER
MmCACNA1H       LEGWVDIMYYVMDAHS-FYNFIYFIL---LIIVGSFFMINLCLVVIATQFSETKQRENQL
CeNCA1          EEGWVYVLYDCMDSLPSYLAFLYFCT---LIFFLAWLVKNVFIAVITETFAEIRVQFS-E
RnRB21          QEGWVFLMYRAIDSFPRWRSYFYFIT---LIFFLAWLVKNVFIAVIIETFAEIRVQFQ-Q
CeNCA2          QEGWVYVLYDCLDSLPSFLAFFYFVT---LIFFLAWLVKNVFIAVITETFAEIRVQFS-E
NtTPC1A         -------LYFIFTRFDFLWSLNYLAL---VVLN--FFEKPLWCSKHLAESCNNRDY----
AtTPC1          -------YYFIFTRLDLIWSLNYFAL---LFLN--FFEQPLWCEKNPKPSCKDRDY----
OsTPC1          -------FYFVYLRLDWLWSLNLFAL---ILLN--FLEKPLWCRGYSQHACDQRDL----
CfTPCN2         --------------AASRWDLCFDQA---TVFIEDAIQYRSINHRMDARSMWLYRL----
HsTPCN2         --------------AAARWDLCIDQA---VVFIEDAIQYRSINHRVDASSMWLYRR----
Tt10302         LEGWTQIMYQLFDAFS-VFTVIYFVL---LVFIGSFFLINLTLAVIKAKFSDNQGTTIVV
Tt8511          LEGWTQIMNLMQSVYIGAFFLMNLTM---AIIGVKYTESISNQQSKVDKNQTSQEQETGY
Tt8517          NEGWSTIMYYVMVGFN-FFAFIYFFL---IVYLGTWLLVNLCMGIIAVKYTESIANQNTM
Tt8516          NEGWSTIMQFVMVGFN-FFAFIYFFL---IVYLGTWLLVNLCMGIIAVKYSESIANQSIQ
Tt11012         QEGWSTIQAQVQQTFG-YPSFIYFMI---CVLVGNMFLENLLMAIIQIKYEESERLLKKR
Tt27559         VEGYYNVLYMMEDSHDQFIPIIFVTC---YFLVCTYFLNNLIIAIFFIKYQQIESEEEKK
Tt14193         MLRPLKLIYHIKPYKKQLERFIRSVS---LLGESIIRLFIFMVFFTILGLNIFKGSLEYR
Tt27255         INGWVATTNIFWRAQDKTVSGIYFVS---LVLLLSQIFSNIVLATLYEGFMDSNTSGKQS
ScCCH1          ANTFTDLMYYTMDSDE-MAACLFFIV---CIFVLTIWLLNLLIAVLVSSFEIANEEYK--
20.m03897       LEGWSEVMYRLADGDGTFRGVLIYILHHSVVILGNLLLMNLVVAVMWESTLLQTNK----
583.m05406      SSSSAACSSSVSPLCSSAWDSPVASAEAPRASVAAHLSASAFAASVSRHESDEETRPRRG
Tg3277          RPRQETVALPPLPRSSVAHAGLAADSGKSLHFREAEVVAALAPASFARTLSRLRTRGRTR
                                                                            

HsCAC1B         -----------VENRRAFLKLRRQQQIERELNG----------YLEWIFKAEEVMLAEED
CeEGL19         -----------ARARGLFQKFREKQQLEEDLKG----------YLDWITQAEDIEPVNED
CeUNC2          -----------VENRREFLKLRRQQQIERELNG----------YLEWILTAEEVILKEDR
DmCA1A          -----------VERRMEFQKCRFRAMFQTAMVS----------YLDWITQAEEVILAEER
DmCA1D          -----------AKNRGDFQKLREKQQIEEDLRG----------YLDWITQAEDIEPDAVG
MmCACNA1D       -----------AKARGDFQKLREKQQLEEDLKG----------YLDWITQVEDIDPENEE
RnCAC1B         -----------VENRRAFLKLRRQQQIERELNG----------YLEWIFKAEEVMLAEED
MmCACNA1A       -----------VENRRAFLKLRRQQQIERELNG----------YMEWISKAEEVILAEDE
CeCCA1          ----------MLQERKMLLNRDSISCTGSEIGGASSKEEGDTVYAAFVRFIGHTFRRTKR
MmCACNA1H       ----------MREQRARYLSNDSTLASFSEPG---------SCYEELLKYVGHIFRKVKR
CeNCA1          ----------MWQKKEVTLDEGFRKKLEKTDDG-------------WRLIRLDGE-----
RnRB21          ----------MWGTRSSTTSTATTQMFHEDAAGG------------WQLVAVDVN-----
CeNCA2          ----------MWQTREATTDHVYTQKLEKDEDG-------------WKLVEVDKYN----
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ----------QENEEEPEMTIDILREYRSLERHYLKTIDPLNDHLAKQRERLNIESFREE
Tt8511          ----------NIKDMIEWGIYKSNKVYYKELEEENKKQHSLFGFTETFGMLADKFKSLLL
Tt8517          ----------VAIKKDGEEGYNMQNLIRWGIYKSNK---VLYKELEERSEKKNPTKLNQP
Tt8516          SSIKGNQEGYNMQNLIRWGIYKSNKILYKELDEQKKKKKNWFDLSFSMSSLLASYKRKSQ
Tt11012         QKAIEDVQSFNLADFIRWGIYKSNKQVYKELEEKKIKKVSTLSEIISFFKQGAQIKKLFT
Tt27559         ----------NASQKRKSNSVRFQGSQQHQQYDAITNNQSLATNSFYNLKGGAADSSNKN
Tt14193         -----------CRETPNPPENSEIWQVAEDVPFLCGYWACPGFQLQKGIKNFREYKLIIA
Tt27255         -----------SKEGGESTLQNDKESKASPTQK----------KSIFKKKQKNASKFTKH
ScCCH1          -------------KKKFIYGSRKTGYVARIVTG---------------------------
20.m03897       --------------SRAVDAKKEDLQMFEILG------------LEWIRFLLQKAEDNEV
583.m05406      E---------REAARDAAREAARRSSRADEATSP---------RSAFIDLCGSFAEGGSR
Tg3277          -------------EGEETGAVLEREVPNEDGPE-------------CAPVAATPCVPEK-
                                                                            

HsCAC1B         RNAEE--------------------KSPLDVLKRAATKKSR-------------------
CeEGL19         EQEDE--------------------PVAQTVVGEEAD-----------------------
CeUNC2          TTEEEKAAI-----------MEARRRAANKKLKQASKQQST-------------------
DmCA1A          TTEEEK-------------------MHIMEARRRNAAKRKK-------------------
DmCA1D          G-------------------------LISDGKGKQPNEMDS-------------------
MmCACNA1D       E-------------------------GGEEGKRNTSMPTSE-------------------
RnCAC1B         KNAEEK-------------------SPLDAVLKRAATKKSR-------------------
MmCACNA1A       TDVEQR-------------------HPFDGALRRATLKKSK-------------------
CeCCA1          AAKKKYT-----------------AYMEERAERKSSERQQRRKSKLDDMATLSR------
MmCACNA1H       RSLRLYARWQSRWR----KKVDPSSTLHGQGPRRRPRRAGRRTASVHHLVYHHHHHHHHH
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         QQKRGFVWEDLAKLRMLQKQKQKENYLKEERLRKKLFVEQWRNKQKSKIQQATKKIAKFY
Tt8511          KQSSSGKLSQDDTKKNNKQSLDNLEQVKEYKVKMNNSHHSIPQLQPQLQASINGDNIFSK
Tt8517          KAIEQKQLNKVVPLALNQQSQDLFINSENNEDSKNPIIKQQQMDRINSADNNGKNGSSQS
Tt8516          KFETPQLQGIGSQEQHHLKHSKILPLDLNTQTESKIYPKTENDQKINQNEQTPKINLIEK
Tt11012         ITKSKSNSGSPNNKDKQIEENIHNFKSIEELENQSADKNQAEKLGKEQKVQQQPANLGTQ
Tt27559         VNRIYPEKITLNTEKQIQNTFIGLNLNSKQQIINPPYKRRN-------------------
Tt14193         QKQEQKN------------------RVKLRNLENEMSKIMLE------------------
Tt27255         SNDS--------------------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       LR----------------------------------------------------------
583.m05406      RQDAR-------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ----------------------------------------NDLIHAEEGEDRFADLCAVG
CeEGL19         ----------------------------------------------EEGEERVED-----
CeUNC2          ----------------------------------------ETEEDFEEDEDEMEEEYVDE
DmCA1A          ----------------------------------------LKSLGKSKSTDTEEEEAEED
DmCA1D          ----------------------------------------TENLG--------EEMPEVQ
MmCACNA1D       ----------------------------------------TESVNTENVSGEGETQGCCG
RnCAC1B         ----------------------------------------NDLIHAEEGEDRFVDLCAAG
MmCACNA1A       ----------------------------------------TDLLNPEEAEDQLADIASVG
CeCCA1          ------------IEEKAEDE-------------------EDETTITRENGDDQIEQNGDG
MmCACNA1H       YHFSHGGPRRPSPEPGAGDTRLVRACVPPSPPSPGHGPPDSESVHSIYHADCHVEGPQER
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         RIIPQFQLLSAATPQQKSNNQIYALPIAEQSNEDKTNNQDQNIEQLNEQNATTQQINNNP
Tt8511          QQLIEKEVDNKENQQNNLVRTLSQAPRIPIENIDNFQIKFTEQPKQKTLVQGGQARNLRN
Tt8517          KNQGNSEDQNLQQDKNENMRQLTNLENGDQQQIHKNYKNLHENNNKNHHNTKILKEAAPL
Tt8516          TPINENQQEEQNKNSDEKNSVNKKQAVLNGNDNRSNGNSTPLSAKVQLSLGIIRQNSNLN
Tt11012         FEQSKPLIEQELQEIHDQNLNTFKSQETNLNLLLKIPMIGLKESQLSVFNNYNSNFSPTY
Tt27559         -------------------------------------AKQLEELNREKNYGQSIELKQNK
Tt14193         ----------------------------------------KENEKKKILEQKQQEKNNAS
Tt27255         -----------------------------------------EQEQEKMRKQGLMLISQIS
ScCCH1          ------------------------------------------------------------
20.m03897       -------------------------------------------SEAKIMEFLLVHRHGVP
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         SPFARASLKSGKTE-S--------------------------------------------
CeEGL19         ---VRPSKWAARMK-R--------------------------------------------
CeUNC2          GGTVEDEFAERKKRGC--------------------------------------------
DmCA1A          YGDDGYLKTRSKPQGS--------------------------------------------
DmCA1D          MTESRWRKMKKD------------------------------------------------
MmCACNA1D       TLCQAISKSKLSRR----------------------------------------------
RnCAC1B         SPFARASLKSGKTE-S--------------------------------------------
MmCACNA1A       SPFARASIKSAKLEN---------------------------------------------
CeCCA1          VRIKR-VKIEEEPKIKIGNG-------------NSNG-----------------------
MmCACNA1H       ARVAHTIATAASLKLASGLGTMNYPTILPSGAVNSKGSTSSRPKGLRSAGTPGATAHSPL
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ISVSKNKIVPLENINLNGLALNNQTSQSMSEQQDQKIVQYHSQQNQYRNQVTFMGFQTNY
Tt8511          NRSKILTKKISKVDSLLSSTRIVPLNPASNEPNQYKQSRFQKQNIAAQEIKKASSLLSQN
Tt8517          ESKKHLTRNFRNEKKGTQLIDPSVLASDLEMINQESKNNFSTSFILLLLNQFIYLQNKDN
Tt8516          QLNEDAKNSNKKQYEHSKYKSDKQKTKLIVQTTEKKTLNGIVDPSILANKLEFIKTEQIQ
Tt11012         SVAHFSHNIKQNQELANFTYEDQNLNLNKLQKSIHIKDLDQMANNQQSQFPKFNPIMKRQ
Tt27559         QIDQLNNSNNSNNKKD--------------------------------------------
Tt14193         QVKKKVLLIAS-------------------------------------------------
Tt27255         CVRDDQLKYNKGYKLS--------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       RQSEEVATGETDLR----------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ------------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          ------------------------------------------------------------
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         ------------------------------------------------------------
MmCACNA1A       ------------------------------------------------------------
CeCCA1          ------------------------------------------------------------
MmCACNA1H       SLGSPSPYEKIQHVVGEQGLGRASSHLSGLSVPCPLPSPQAGTLTCELKSCPYCASALED
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         FATMQKPLVLSQQLKLQQQLCSSNSSQQMLLNEDEEDHFWKEIEDQKNLFTNKENQKDSL
Tt8511          ---------------------------------------------------------CSE
Tt8517          IGKKRTKKTGTYVRGLRNGTHQNQTNMNPQQKIKKINFAPISKQKPKYKEEKINDDPTPR
Tt8516          ----------------------------------QKKTSKKLISASKDMHPKVESSFQRY
Tt11012         -------------------------------------PQYLKKSSIREKSPKRGYQRKNS
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         -----------------------------------------------------------S
CeEGL19         -----------------------------------------------------------L
CeUNC2          -----------------------------------------------------------C
DmCA1A          -----------------------------------------------------------C
DmCA1D          ------------------------------------------------------------
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         -----------------------------------------------------------S
MmCACNA1A       -----------------------------------------------------------S
CeCCA1          PHYKHSSSDE-ESDEDGEEDQVYDG---------EEAKKKSTP-----------------
MmCACNA1H       PEFEFSGSESGDSDAHGVYEFTQDVRHGDCRDPVQQPHEGGTPGHGNERWRPPLRTASQP
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         SHKESDKQQTSSTSSQTNIQDKQNNNDNNNAKSKSRDDFIAQPSQEQLQQEILLSKQQDS
Tt8511          QDDQHLSQTNEDKVNKKRSNSQNKELNSNQNELISPEILQEQLDQISSKDGNQNYYSNSR
Tt8517          EDQNYLAVEQDNDEENRRKSRNVPSQIVDIRRQSKKIKHLFKQKDEVSEDQLKLDDDIFL
Tt8516          YELQNQKMDQKKLNFAPIQKQKPQQQEQKPSLNKIQAAHKETNEGQQISRKKSKNGHEIR
Tt11012         RKMTTKKTMIIKPLEGTQTQIRNSVSNNNNTQIRLTVAKNMNSSHQSRNPSEIHQNSQLN
Tt27559         -----------------------------------------------------------L
Tt14193         -----------------------------------------------------------I
Tt27255         -----------------------------------------------------------L
ScCCH1          ----------------------------------------------------------YW
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         SYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQP----RRLTTTLYFA
CeEGL19         EKLNRR---CRRACRRLVKSQTFYWLVILLVLLNTLVLTSEHYGQS----EWLDHFQTMA
CeUNC2          HSVGKFIKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQP----QWFTDFLKYA
DmCA1A          TGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQP----SFLTEFLYYA
DmCA1D          --FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQL----DWLDNFQEYT
MmCACNA1D       --WRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQP----DWLTQIQDIA
RnCAC1B         SYFRRKEKMFRFLIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQP----QRLTTALYFA
MmCACNA1A       TFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQP----EWLSDFLYYA
CeCCA1          ---SKLWW-FREKIQKFVICDHFTRGILVAILVNTLSMGVEYHQQP----EILTVILEYS
MmCACNA1H       GGLGRLWASFSSKLRRIVDSKYFNRGIMAAILVNTLSMGVEYHEQP----DELTNALEIS
CeNCA1          ----VEPEGPKQKLQWMLRSMYFQCFVIIFVVINAIGNAMFVYRHDET-DKPRKYNFYLF
RnRB21          ----KPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENF-RR-QYDEFYLA
CeNCA2          ----RAHSNNSLFLHTIVTSTAFQTVMQLLILANAIFHATFVFYHDES-DQIRKIWYYYV
NtTPC1A         --------YYLGELPFLTGAESLIFEGVTLLLLIIHILFPISYEGF---NLYWRSLLNRV
AtTPC1          --------YYLGELPYLTNAESIIYEVITLAILLVHTFFPISYEGS---RIFWTSRLNLV
OsTPC1          --------YFLGQLPYLSKTESLIYEGLTLVILVMDIFYPLSYEGL---NLFWKNTINKL
CfTPCN2         --------YYSNTCQWILSFTIFLILFLAFIETPSSLTSTADVRYRSPPWDPPCGLTESI
HsTPCN2         --------YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV
Tt10302         AVKSILNKTDSTRSRESVLDHSSPKKFSILNLKSQKKSNSHSTKQKTEKPEAILKKFSIS
Tt8511          KSSSVQRSAAKNKSSNSYSPNKNYKQIVAGDRIIHLAPIYSQSSQFKKNKRKQTVISENE
Tt8517          LQLEQKEKFTKNDLIGIEDEEIENIHFKKLQNDFKSLRQNKQIEQRSASSKKNSHQTNFQ
Tt8516          RASKKLNNMFQFQENFKEEEEESDEDFLMQIENCKEFNNQNGINQNDDQQIEENYLNQIH
Tt11012         QTNFQRDKSVNQNTYISNNTYHQGSNQQTIMLQPSVILKSKQNRNSNVLNILNSQIIPAR
Tt27559         KKHLEYSKKVSLKSIAEEKDIFYMKQNSIYKQLYNLFLNIKKFRDRNVAEELKKFKQLYA
Tt14193         ASKFKKIGSSQKNEISDAQQPNSNLQISVNNELNNAGEQQNQISSEEFEDPPLLVKIYMS
Tt27255         FLQSIYKYAKQFRKSTLFSFLHFVNIISIIVVLCIDNIQIEGYEYVKLNKADFIVTMIFF
ScCCH1          KYFKLKANQTKFPNWSQKGLAIYSHVEFIFVILIICDIGMRASVKVSTSANCNNILLKTD
20.m03897       -DEDDCSSKLGRCWISVWQTVYTIVARKQYATLVFLISAADALFIIIADAVELMDTYRSV
583.m05406      ---VSHKREARETCRHAGDAERLSRTSQALPGGVSPRCASPSCRSLSSRRKEAFLALASN
Tg3277          ---EREKERGRERRLVEGSTEEGRRGADAGFLGPSGEREWREVSLEDESAQPMVSFAPGQ
                                                                            

HsCAC1B         EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVL
CeEGL19         NLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMKPLGVSVL
CeUNC2          EFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEVIWAEVYGG-SFGISVM
DmCA1A          EFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGS-FGLSVL
DmCA1D          NVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVL
MmCACNA1D       NKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVF
RnCAC1B         EFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVL
MmCACNA1A       EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVL
CeCCA1          NLFFTALFALEMLLKIIASGLFGYLADGFNLFDGGIVALSVLELFQE-----GKGGLSVL
MmCACNA1H       NIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVVISVWEIVGQ-----ADGGLSVL
CeNCA1          EVGFTILFNVECIIKILCYGFRNFIRRGIFKFELILCLGSSLNCVKF------FYERNYF
RnRB21          EVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPD------LYHS-QF
CeNCA2          EVGFTILFNTEVIIKIYAFGWKAYIARGQHKFDCILCVGSSLNAIWV------LYETNIF
NtTPC1A         KVILLLILVADIVVYILFLA---------------------------------DFYYLPF
AtTPC1          KVACVVILFVDVLVDFLYLSPL-------------------------------AFDFLPF
OsTPC1          KVLLLFILACDILVFAFSPQ--------------------------------------PF
CfTPCN2         EGLCLLVFVADVSVKSYLVGWAQFQKNLWLLAYMVVLVVSLMDWIVS----LGLVCQEPL
HsTPCN2         EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS----LSLVCHEPL
Tt10302         SQGSIMLESHNSIIEFQDQELSKQNSDQPLKLNLASTEGDEIQFTTRLQNVKSHINANHN
Tt8511          NMLNSKRLSQNMLQSKRMSQIGGDIRLQRDSLNQKSNENSLLKADQGTQEFNKELRRKSK
Tt8517          NHSEEPKQVHQKSKRNTSVSLQKKRENMLNGERKKDKSKSSRNQLQETESSADSLSDVSK
Tt8516          NTLAFQSLKQKKLEKKKQHDPNLENKKRENNEIAMYSHSQDSKVKKNSENRSSSLNIQKK
Tt11012         KVESDEGSSIDSHQNKDFDEEEQFFKEIEKTYEINQKLNRQLELKETEDNQYIENIIKDR
Tt27559         SEFLDKSISRAETNKNKNNGIQDQCVFQFKQKKNIQQNSIQSFNKSQQKENELDYNRGII
Tt14193         FAYQYPISQAESDVYLIIQLCLNLLFIMEITFKVLLLQRDYFKSWLNVLDSIIVMVITSI
Tt27255         SFSFIELITQGKKYFEQKLLLLDAFIILITSISYIVESSKGYDIFNP--QVQTFIFIRWI
ScCCH1          RGISIVLFIESLARLVLYLPNMWKFLTKPSYVYDFIISIITLVISCLAVEGVLGHMYAWL
20.m03897       NCFFVMCYTVDAILQLVAFGCREFVRDGFKIFDLVLAVVGVIEVLFSLVVCGGFATCYDA
583.m05406      ADLCSTGRGEDKERRREKEREDPQEKATGDASKVEIEGTLPSAASVSLDRPSRDLSAGDW
Tg3277          NRMRHLRYQRSSSWEPSTAAAFGSQPPTGTGANRAPLRAGLARAGLQGPSPPAQNGAANS
                                                                            

HsCAC1B         RALRLLR---------------------IFKVTKYWSSLRNLVVSLLNSMKS-------I
CeEGL19         RSARLLR---------------------IFKVTKYWTSLRNLVSSLLNSLRS-------I
CeUNC2          RALRLLR---------------------IFKLTSYWVSLRNLVRSLMNSMRS-------I
DmCA1A          RALRLLR---------------------IFKVTKYWSSLRNLVISLLNSMRS-------I
DmCA1D          RCVRLLR---------------------VFKVTKYWRSLSNLVASLLNSIQS-------I
MmCACNA1D       RCVRLLR---------------------IFKVTRHWTSLSNLVASLLNSMKS-------I
RnCAC1B         RALRLLR---------------------IFKVTKYWNSLRNLVVSLLNSMKS-------I
MmCACNA1A       RALRLLR---------------------IFKVTKYWASLRNLVVSLLNSMKS-------I
CeCCA1          RTFRLLR---------------------ILKLVRFMPALRYQLVVMLRTMDN-------V
MmCACNA1H       RTFRLLR---------------------VLKLVRFLPALRRQLVVLMRTMDN-------V
CeNCA1          TYFQTFR---------------------LLRLIKASPILEDFVWKIFSPGKK-------L
RnRB21          TYFQVLR---------------------VVRLIKISPALEDFVYKIFGPGKK-------L
CeNCA2          TYFQVFR---------------------IARLIKASPMLEDFVYKIFGPGKK-------L
NtTPC1A         RIAPYLR---------------------VVFFILNIRELRDSFFILAGMLGT-------Y
AtTPC1          RIAPYVR---------------------VIIFILSIRELRDTLVLLSGMLGT-------Y
OsTPC1          RVAPYIR---------------------VAFLIMNIRELRMCAVTLVGMVGT-------Y
CfTPCN2         RIRRLLR---------------------PFFLMQNSSMMKKTLKCIRSSLPE-------M
HsTPCN2         RIRRLLR---------------------PFFLLQNSSMMKKTLKCIRWSLPE-------M
Tt10302         VMSPMHQNLINFNSQSNDTPKNELQKQETKDMNDSLLNDSDFFQNPEKKQEQ-------T
Tt8511          RNNQISN---------------------MILDSMNSSSKRNSISKLYDSVNSDQFAQDDF
Tt8517          MSFLEMDDT------------------LIDKTPRNKTTVINNLYQEFDIKIGKTSKKLQE
Tt8516          KDFTFKRGTKEISNSNNTN-----KMSQNTETNSNEESLSDISEMSFLVQEDQEQERNVK
Tt11012         QIERNYRQKTVTLDN-------------LINNQINKQPLHHDQLSLSSIQESYQKDTPEE
Tt27559         DIFLSNK---------------------IFLVFINLCIFCNIIVLSFNQYPAVSDSFYSI
Tt14193         NIYYLVR----------------------LCEGLENPLESESLRGLQTAKSIEILRIFQL
Tt27255         KMLRILR---------------------LINEFSIFGSLKILLHTYYYTLAS-------L
ScCCH1          SIFHISR---------------------FYRVIISFNLTKKLWKQILSNGVM-------I
20.m03897       DADNARDVVKTVDLVLN-----VLHSFRLFKLVRNFTSLRLLLEVIADLLRS-------V
583.m05406      EPRRPLLP--------------------AFLFRADASCLHSPSPESLLPELDPWSQRTIL
Tg3277          RSGGPAHWG------------------AVPNACSSFATGSSPASAAGAVAVP--------
                                                                            

HsCAC1B         ISLLFLLFLFIVVFALLGMQLFGGQ-----------------------FNFQDET-----
CeEGL19         ISLLLLLFLFIVIFALLGMQVFGGK-----------------------FNFNPQQ-----
CeUNC2          ISLLFLLFLFILIFALLGMQLFGGR-----------------------FNFPTMH-----
DmCA1A          ISLLFLLFLFILIFALLGMQLFGGQ-----------------------FNLPG-------
DmCA1D          ASLLLLLFLFIVIFALLGMQVFGGK-----------------------FNFDGKE-----
MmCACNA1D       ASLLLLLFLFIIIFSLLGMQLFGGK-----------------------FNFDET------
RnCAC1B         ISLLFLLFLFIVVFALLGMQLFGGQ-----------------------FNFQDET-----
MmCACNA1A       ISLLFLLFLFIVVFALLGMQLFGGQ-----------------------FNFDEGT-----
CeCCA1          TVFFGLLVLFIFIFSTLGMVLFGCK-----------------------FCNHPDTGLQCT
MmCACNA1H       ATFCMLLMLFIFIFSILGMHLFGCK-----------------------FSLKTDSGDTVP
CeNCA1          GGLVIFTIAFICCYSAISLQLFYSV-----------------------PNLHHFR-----
RnRB21          GSLVVFTASLLIVMSAISLQMFCFV-----------------------EELDRFT-----
CeNCA2          GGLVIFTGILLIVTSAISLQLFCYV-----------------------PKLNKFT-----
NtTPC1A         LNVVALSALFLLFSSWLAYVFFEDT-----------------------RQGKTTFT----
AtTPC1          LNILALWMLFLLFASWIAFVMFEDT-----------------------QQGLTVFT----
OsTPC1          LNVLALSLLFLLFASWLAYVTFEDT-----------------------PQGKTVFS----
CfTPCN2         ASVMLLLALHLCVFTMFGMLLFTGE-----------------------KQDHGQDR----
HsTPCN2         ASVGLLLAIHLCLFTMFGMLLFAGG-----------------------KQDDGQDR----
Tt10302         ENYEYLAQVLKNLNEKIANRLKNDSDEDNNYENRNDDFEDNDENQEDDFNLKRQNKFRGG
Tt8511          LKEIEVQEKILRYNQKYNENEINEKLNNDAQIENNYSSNKMTINQLKSRKLKQNDNQDQT
Tt8517          KKATKLLTQKQITPSIKHLKTYNTQEQENFEAPKIEEQILKKINKQIDLKAEDFKLMLDS
Tt8516          PQLNRKSTMLNNMFNELEIQVLKNKKLNFENKQKNVQGQGHRKSTKNVKQVTEKYESLLS
Tt11012         QNLMFQSIQKRSFKKKREVSIQGQLQSSEISRPYDPESPKKAMSSKRIKQLPNIPSASLN
Tt27559         LNALRLLSSKQNYYILLGEIIIDVTSTVIVFKTKDLVPFSCLKGIRILYAFTNIQKWVNY
Tt14193         SYYFLIIIAYCVLFALIGNYLFAFYAY---------------------FDANEEIAHDKS
Tt27255         PEFLFLWVLLIVLFVQIGRELLAGMDGGD-------------------EHFDEEE-----
ScCCH1          WNLSSFYFFFTFLVAIIMAVYFEGVIPP--------------------EEMADQPFG---
20.m03897       VFFYALLLFHVYVFATVGFALFFDPKYG--------------------ADVWSIEVT---
583.m05406      LALSFLCLGVLLLAALLECIYRGEMSEDE----------------PRGAPLGEDDGASKA
Tg3277          -DLAASVALQHQMVRLAEELLYSPEES---------------------FHSGPVQRG---
                                                                            

HsCAC1B         ----------------------P--TTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQG
CeEGL19         ----------------------PKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFG
CeUNC2          ----------------------P--YTHFDTFPVALITVFQILTGEDWNEVMYLAIESQG
DmCA1A          ----------------------GTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQG
DmCA1D          ----------------------EKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYG
MmCACNA1D       ----------------------QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYG
RnCAC1B         ----------------------P--TTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQG
MmCACNA1A       ----------------------P--PTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQG
CeCCA1          S-------------AQVISSICECDRMNFDNFLFATVTVFQILTQEDWNMVLFNGMAQT-
MmCACNA1H       ------------------------DRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST-
CeNCA1          ------------------------------TFPQAFMSMFQIITQEGWTDFVVEVLRATD
RnRB21          ------------------------------TFPRAFMSMFQILTQEGWVDVMDQTLNAVG
CeNCA2          ------------------------------NFAVAFMSMFQIITQEGWTDVVIEILRACN
NtTPC1A         ------------------------------SYGTTLYQMFVLFTTSNNPDVWIPAYKDSR
AtTPC1          ------------------------------SYGATLFQMFILFTTSNNPDVWIPAYKSSR
OsTPC1          ------------------------------SYGTTLYQMFILFTTSNNPDVWVPAYKSSR
CfTPCN2         -----------------------ERLIYFRNLPEALTSLLVLLTTANNPDVMTPAYSRNR
HsTPCN2         -----------------------ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNR
Tt10302         A-------------TFKNNKQTFSKKPDYSPVVDKKDKIRKGNDQDNFNKIIHEVEEEED
Tt8511          ENYQVLP-----EKLKLDNTRKEKHEQKQNDVSIQMIQQYRRDRKDKSKESVSNSIQSRR
Tt8517          KYLKPR------------VVYRQTNEYEGDVQPTKLNKQIQKLKNQQEEKIKRLKFRVKQ
Tt8516          QETN---------------NIEQQLQSKINKQIDQKAEDFRLLLDTKYLKPRVIYAETND
Tt11012         TSSKIQK-----SSHVSIILENSLNNSKQKQIRSASQTDFKVDSKQSILEQRKNSYFYDG
Tt27559         RILIDAMNHSMSYVRQLECGYLEENSNLMTQMNMTSSMVFTTIQGDQWNRVWFDCVRSEG
Tt14193         E--------------------GKSPRINYDSFLDSFEAIMLIILNDEWADQMYYYMRSLG
Tt27255         ----------------------TIIRINYNTLHNSLIAVIMICYNEEWQLVMYKYRRIVG
ScCCH1          ----------------------------MYSLPNSFLSLFIIGSTENWTDILYALQKHSP
20.m03897       ------------------------KYSNFKTIWQALLLVFGLLTGESWNVAMREFYSVYI
583.m05406      S---------------------GEKEDRGEGGEEGDRGEERLLSKTFLKRTSSESVSLDE
Tg3277          ---------------------AHPSSSAYPPASFTFHEQQQSLFHLDKTRVPVLASSGSN
                                                                            

HsCAC1B         GVS-K------------------------------------------GMFSSFYFIV---
CeEGL19         GVGTL------------------------------------------GVIVCIYYIV---
CeUNC2          GIYSG------------------------------------------GWPYSIYFIV---
DmCA1A          GAQK-------------------------------------------GMIYSIYFIV---
DmCA1D          GVSSY------------------------------------------GALACIYFII---
MmCACNA1D       GPSSS------------------------------------------GMIVCIYFII---
RnCAC1B         GVS-K------------------------------------------GMFSSFYFIV---
MmCACNA1A       GVQG-------------------------------------------GMVFSIYFIV---
CeCCA1          -----------------------------------------------NPWAALYFVA---
MmCACNA1H       -----------------------------------------------SSWAALYFVA---
CeNCA1          --DNL------------------------------------------VPLVALYFVA---
RnRB21          --HMW------------------------------------------APLVAIYFIL---
CeNCA2          --EQA------------------------------------------VPFVAIYFVA---
NtTPC1A         -------------------------------------------------WYCLFFVL---
AtTPC1          -------------------------------------------------WSSVFFVL---
OsTPC1          -------------------------------------------------WSSLFFIV---
CfTPCN2         -------------------------------------------------AYAIFFIV---
HsTPCN2         -------------------------------------------------AYAIFFIV---
Tt10302         DEQKTNKNTE------------------------------------RANNIQQFQDE---
Tt8511          INQTASQGSQNESSQRGKTKTNSALDQLSEVSEMSMVQSQNNRGASRSRKNTVTYVPGIP
Tt8517          QSSMIVQKDK------------------------------------KKKLQVQYKMPIQ-
Tt8516          YTPEILPTKLQKQTELFLKSQDEKMKGMRFRLKQQSSLVFKKEKAQKKLQFKLPFSKSK-
Tt11012         LFSDEDFDNVKQFRKQISKKTSIASKTGNNKNKKEKSVKDKNVVDENPKVSIINQVLSKD
Tt27559         -----------------------------------------------SLKAHPYFIL---
Tt14193         ------------------------------------------------QYVAIFWVI---
Tt27255         YKSILYHFLAMLILQ--------------------------------VLFVRLFIAIFIN
ScCCH1          NISST-------------------------------------------FFCSVFFII---
20.m03897       ADAQAIPGSALSSNVIFESSAN-----------------------IYIICMYIFVAVLFL
583.m05406      TSGRG----------------------------------------LLPLFSSQPFSR---
Tg3277          ADSLG-------------------------------------------PWEALSPNG---
                                                                            

HsCAC1B         ---------LTLFGNYTLLNVF-----------------------LAIAVDNLANAQELT
CeEGL19         ---------LFICGNYILLNVF-----------------------LAIAVDNLADADSLT
CeUNC2          ---------LVLFGNYTLLNVF-----------------------LAIAVDNLANAQELT
DmCA1A          ---------LVLFGNYTLLNVF-----------------------LAIAVDNLANAQELT
DmCA1D          ---------LFICGNYILLNVF-----------------------LAIAVDNLADADSLS
MmCACNA1D       ---------LFICGNYILLNVF-----------------------LAIAVDNLADAESLN
RnCAC1B         ---------LTLFGNYTLLNVF-----------------------LAIAVDNLANAQELT
MmCACNA1A       ---------LTLFGNYTLLNVF-----------------------LAIAVDNLANAQELT
CeCCA1          ---------LMTFGNYVLFNLL-----------------------VAILVEGFQESKEEE
MmCACNA1H       ---------LMTFGNYVLFNLL-----------------------VAILVEGFQAEGDAT
CeNCA1          ---------YHLFVTLIVLSLF-----------------------VAVILDNLEMDEELK
RnRB21          ---------YHLFATLILLSLF-----------------------VAVILDNLELDEDLK
CeNCA2          ---------YHLLVTLFVLSLF-----------------------VAVILDNLEMDEELK
NtTPC1A         ---------YVLLGVYFVTNLI-----------------------LAVVYDSFKSELVKQ
AtTPC1          ---------YVLIGVYFVTNLI-----------------------LAVVYDSFKEQLAKQ
OsTPC1          ---------YVLLGVYFLTNLI-----------------------LAVIYDSFKEQLAKQ
CfTPCN2         ---------FTLIGSLFLMNLL-----------------------TAIIYNQFRGYLMKS
HsTPCN2         ---------FTVIGSLFLMNLL-----------------------TAIIYSQFRGYLMKS
Tt10302         ---------QISPSNQQSSQKQ-----------------------KNIQHENGETQLNES
Tt8511          QDEIRQTKPTIIFNDAEFLNIFGKQDHNKETKMHSDQQNKKKHTTVKVQQQNQETQLKRQ
Tt8517          ----RSKRIDTMYAEKMFRDILEGKITTENHSIKQSKVADPKNDGISFETNPFKIAKNIA
Tt8516          --------RVEVLQEDLILDAMLAG---------------------KFTTDNQSIKYSKQ
Tt11012         E---GQLYRKLFLKKDVIARVLYKEPTN---------YDDDILPKEKLIKKEKKKQDRLD
Tt27559         ---------LMVIGKTIFLNSFT-----------------------AIMLASFDYANKKS
Tt14193         ---------VVFTGTMLVMNLLR-----------------------ALFIKTYLKYLYNS
Tt27255         IFMKWLRENEIVLYHSQTLVIIKKLTKQATNFFNSKRNQIQPQQSNTLKENNNIKQQASI
ScCCH1          ---------WFLLSNSVILNIF-----------------------IALISESMEVKEEEK
20.m03897       CCFIYNVFGAVLIGQYVTARKMVFNSHIFQFIKLCRELGIEMPTRAALDRENLQRMYSLA
583.m05406      -------LLILAACLVSLVDLFG--------------------VALVFFLPSLSCTDSPR
Tg3277          ---------PARFGGTVTPGSLLGG--------------------PGYPTRGSEGTFDFD
                                                                            

HsCAC1B         KDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQN
CeEGL19         NAEKEEEQQE--------------------------------------------------
CeUNC2          AAEEADEKAN--------------------------------------------------
DmCA1A          AAEEEQVEEDKEKQ----------------------------------------------
DmCA1D          EVEKEEEPHDESAQKK--------------------------------------------
MmCACNA1D       TAQKEEAEEKERKKIAR-------------------------------------------
RnCAC1B         KDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQN
MmCACNA1A       KDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPTKSVWEQRTSEMRK
CeCCA1          KRQLEEDARKQAVEEEDERKRELELIIAKTTSPAFN-------NGVAP------------
MmCACNA1H       RSDTDEDKTSTHLEEDFDKLRDVRATEMKMYSLAVTPNGHLEGRGSLP------------
CeNCA1          KVKQLRAREATTSMRSTLPWRLRVFEKFPTRPQMAAMRKADS------------------
RnRB21          KLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPS------------------
CeNCA2          KVKQLKAREQDT-IKTTLPMRLRIFNRFPTAPTMVTMKKVSS------------------
NtTPC1A         VADKDR------------------------------------------------------
AtTPC1          VSGMDQ------------------------------------------------------
OsTPC1          VSQADC------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         NSQHQENKEEPIMDNNQNGNHNNQNKPALEISEYQKQRELLQIEWLKKIEKIRQEHKLIE
Tt8511          ESRKIDRKYHANVDEKLDMKKEEMKLLLNSKILKPRVLLEQPNEYTEDIQPQKKQEQHEK
Tt8517          QRSQKGGTSVKNDDEKNDMNFLTQQRQFSTNQNNLFLKQITNKQRVNDVNSQVNNEDSSR
Tt8516          ADQKNDLQSYDSPNPFRQTKMSGFMQKTTLNKAFSSKEEEKNSVALYSQPKQLMPFSPNI
Tt11012         KLKKMKFSISYQAEKRVKLRSQVVEEKKKKMEKMKFLPIKANRTALALIHQQPQVYPGGV
Tt27559         DAAMRGAKTAIDQILSMKLRRK--------------------------------------
Tt14193         NIGIHESVDKLQNAIKKFHKFG--------------------------------------
Tt27255         KNSVEEMQEYQQDGMKGYEKQQNLKNETKMLNQDSQNQKMNGAIQNSQTKKQNQNGNLNL
ScCCH1          RPQQIKHYLKFVYPQKIQEYTHASLVARIRKKFFG-------------------------
20.m03897       SPRMVGQKKARRALSEFLRPRSWSNQERLGFSKASTGAAWMIHRLTRSISRASTLRR---
583.m05406      EPSGAVCAREGLRAFLAWYKPG--------------------------------------
Tg3277          APRRDSTGFWAFTG----------------------------------------------
                                                                            

HsCAC1B         LRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAA
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          ------------------------------------------------------------
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         LRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVVEPGRDGLRGPAGNKSKPEGT
MmCACNA1A       QNLLASREALYGDAAERWPTPYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAPEALR
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ASSSSQFFQLEVLEKRKKEKEEQELKEKMIKEVKNWKLMVDYKHEDEFTSKEDVMELTIN
Tt8511          RRAEQNKKLKSLRFVIKYFSQKKLSKKKQQKKEDLRKLIPYKRSARIDGLNKEKLFAVLD
Tt8517          QQDANSYVNGEHAENNLNGQQENSRLNNDSAAAQSNQAKSVNGEYEQKGLVLKRTFKDEV
Tt8516          NAKQIFLKQQFNFESNIQSQVDDKKAQSIVSKQDNNYQKDLNNSINQDLDALNSPSNQAK
Tt11012         NPLDLAAAQNKIKSQTLIGQQNTQKNNHENMSQGTYNRAPSIVQQLLKQQTLILQKGKID
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         PKIIHTTSIEKIDEIQMKKQNLKRKQSLEMLRESTQPSINVIMSRSKSNENLIDQKQQQS
ScCCH1          ------------------------------------------------------------
20.m03897       -----------------------------------------------------RSQRLSS
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         EAPE----GVDPPRRHHRHRDKDKTPAAGDQ--------DRAEAPKAESGEPGAREERPR
CeEGL19         --------------------------IEGED--------EEFEEGEDEGEEHGMDE----
CeUNC2          -------------------------EIEEES--------EELDEQYQEGDHCTIDMEG--
DmCA1A          ---------------------LQELEKEMEA--------LQADG--VHVENGDGAVAPS-
DmCA1D          --------SHSPTPTIDGMDDHLSIDIDMEQ--------QELDD--EDKMDHETLSDEE-
MmCACNA1D       --------KESLENKKNNKPEVNQIANSDNK--------VTIDDYQEDAEDKDPYPPCD-
RnCAC1B         EATEGADPPRRHHRHRDRDKTSASTPAGGEQ--------DRTDCPKAESTETGAREERAR
MmCACNA1A       PTARPRESARDPDARRAWPGSPERAPGREGP--------YGRESEPQQREHAPPREHAPW
CeCCA1          ------AECTCQRPSSPEESP--SPRLLSAN--------YHPSPERKHSANLDAIIDKR-
MmCACNA1H       ------PPLITHTAATPMPTPKSSPHLDMAH--------TLLDSRRSSSGSVDPQLGDQK
CeNCA1          --------DFPMPKVRGSFTHQFAVDHSLET-------TDVIESDFEFPKRIMKSAGK--
RnRB21          --------DFTVPKIRESFMKQFIDRQQQDTCCLFRILPSTSSSSCDNPKRPTVEDNKYI
CeNCA2          --------EFPLPKIRDSFTRQFADEFVETS--------DDTIQEIGFKVRSMLSGRG--
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         QQLKNKEEEEEQRLRQLKYKILHKLKVVKKKKKLTKRSIQNGNKASNDNSVRENSPHPNT
Tt8511          NQNIEEIYQNKLSINLDKGNNFNNFDNKSYHSHKNQNIDDKIKGAPSSHNIIERIQHQEG
Tt8517          DQMDNKSQKNSLNGSIAQGSVDERQNPNNKSLNQANTSFRSKLTNKQTERKINVSGNIQV
Tt8516          SVKDYSEIKDSPRKDGKKEIFINGGEDKNDKSVRSSKNVSIVQSNEQDQQNFTSRMQSLR
Tt11012         DEKVRLQGDASQKNNLIPQSALSLEYFENQEKIKKGLNLIIPDSDKNSQSNTGSQQVIEA
Tt27559         --------NSELPQEMQKKDFIKNDTYKNIN--------SKFVSKGDDDSQSKEDNFKSS
Tt14193         ----------------------------------------EVQTPLPQNDHPGIQN----
Tt27255         SRETSSKHQNQLIAYRKINTHSHASTAFNIVLNNDSSEKDQIAEPINQENKNDQKQNNIF
ScCCH1          --------GHRNEDTRDFKQFLMRGTAIMNIAQNMGELADEFKEPPSENLFKKGLSKLTI
20.m03897       EGRRTTKRKAGKARQGQRIPDTQRQQRAYRVLADVFPWRQKKGRSKQGGPYSAIEGKNVA
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         PHRSHSKEAAGPPEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKEC
CeEGL19         ------------------------PEG---------------------------------
CeUNC2          -----------------------KTAG---------------------------------
DmCA1A          -----------------------KSKG---------------------------------
DmCA1D          -----------------------VREM---------------------------------
MmCACNA1D       -----------------------VPVG---------------------------------
RnCAC1B         PRRSHSKEAPG-------ADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKE
MmCACNA1A       DADTERAKAGDAPR--RHTHRPVAEGEPRRHHARRRPGDEPDDRPERRPRPRDATRPARA
CeCCA1          --LVLRNS--APFDRSPVSEGRDDSR--LNRHASLVLPVANG---VPYRRQRVHSWSGLC
MmCACNA1H       SLASLRSSPCAPWGPNSAGSSRRSSWNSLGRAPSLKRRSQCGERESLLSGEGKGSTDDEA
CeNCA1          -RKISKSGLTFRQIGSTSLRCSLNNLLEMSDRTRQSLSNSLSFLPHFTRSSGSLYPRKDA
RnRB21          DQKLRKSVFSIRARNLLEKETAVTKILRACTRQR-MLSGSFEGQPAKERSILSVQHHIRQ
CeNCA2          PSKETRITTTIRHVGQLSNKTILTSMLTESNRNRALFSESNQHLASLTRSNTSSKHGKSG
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         SMRAKERIQKLKRLQQMISNAAMSKKSGLNQNSIFQADQSGIRRKNDSNTVKDFKDNKSV
Tt8511          LEPSINQAQSSEKYQENNLEDVSQNNYNINLSDRKIDSTPAVQLKYDENTLNRLKSKKSI
Tt8517          SKKGKNQKGDEIENDWNLEKAIQKIFMEEQVLEKDPLLDEKPNGDQKLQKIVNIQTAQVD
Tt8516          NRNDSNQSNQDQLNSSLRSKIIAKPTDKKLNTSGAIFQQKKGKNQKGDEVENQWDIQKAI
Tt11012         NLIQKKGTLGNNDQSDQLLKANLTPKTAKGILKIKSITGNENSNLNTELNRSQTNKQLDE
Tt27559         VVDSEKQDDKFSLKAQQKKRKVLQQDNNEN------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         LLTPQRSIYNRSKSGENENRNNQDEFNKIEHAKFNIQSHNSSQKRTRHSQLPSISLQSPL
ScCCH1          GVPSLKRLRMFANNPFYKNSDVVFTETNDINGRTYILELN--------------------
20.m03897       GQGIRLGATGDCRGKERRVARPSASLSSSSISERQCSTRADNFGGLWAVGHDVRPGDGAG
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         AGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAE
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          ------------------------------------------------------------
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         GKEGTAPVLVPKGERRARHRGPRTGPRETENSEEPTRRHRAKHKVPPTLEPPEREVAEKE
MmCACNA1A       ADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQD
CeCCA1          HHFNPNCPVH------------------GRRALIETYAR---------------------
MmCACNA1H       EDSRPNSGTHPGASPGPRATPLRRAESLGHRSTMDLCPPRPATLLPTKFRDCNGQMVALP
CeNCA1          LPKSRSMTGKFLQTAVRNKQFNMYSENGDLSRPSDSAPKKNAKQGEIDIRALQQKRQLAE
RnRB21          ERRS-LRHGSNSQRISRGKSLETLTQD-----HSNTVRYRNAQREDSEIKMIQEKKEQAE
CeNCA2          ALSTNSRSRTRGLASLKGKHMVEGFKENGDLRPEDTAR-KVEKHGEIDFKALQMKRAHAE
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ITFSKFAGFQSPQASVKGDNKGKAYQGAFQRFNKSFNSTNSIGSVQDDVHRLKIPIKMSN
Tt8511          IDEIKKQDESIDSISQKKHQYSSTKPIRLNSNQDRAGKKKKVETEIKWEQWDYQHALNKI
Tt8517          VPAKNIQQKSQHDIFMYQLEQKFIKKAERQLDILNNHEPSQSQTDIKSVKSADTGIHSFS
Tt8516          QKIFTDQTELEKDEQQQQQDDQDQKQTNLKGQKTQVQSTKAQQQKNTYDVMMYQLEQKII
Tt11012         SLLNKKKTSGYTGNTGRHQGDNPAFEWDLIKAREMLFPTDHEEEEKSQRESEFSQVFGDN
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         NSSTVFPFINQNCINEIIKQSSREQFQSDAESYPSQSKYDRLLIMSLESLKSQENNDKLS
ScCCH1          ------------------------------------------------------------
20.m03897       IFYRADTPSGLPATEHRAASEETDLGGSLSFCESVCYLFSLSLIYFCDTIIRLVSCPFKR
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         IVEADKEKELRNHQPREPHCDLETSGTVTV------------------------------
CeEGL19         ------DEEMTSARPR--------------------------------------------
CeUNC2          -DMCAVARAMDDLDEECE------------------------------------------
DmCA1A          ---KKKEEEKKEEEEVTE------------------------------------------
DmCA1D          ---CEEEEEVDEEGMITA------------------------------------------
MmCACNA1D       ---EEEEEEEEDEPEVPAG-----------------------------------------
RnCAC1B         SNVVEGDKETRNHQPKEPRCDLEAIAVTGV------------------------------
MmCACNA1A       LPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIG--NSTNPGPALATNPQNAAS
CeCCA1          EKFLEASQELKQALAEEEK-----------------------------------------
MmCACNA1H       SEFFLRIDSHKEDAAEFDD-----------------------------------------
CeNCA1          ITRNRIEEDMRENHPFFDRP----------------------------------------
RnRB21          MKRKVQEEELRENHPYFDKP----------------------------------------
CeNCA2          ITRNRIEEEMRENHPMFDRP----------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         RIICFDQFSSHQGDDLSVSEAQSGSVSNQNNNQSNSLTVRNTKFIISQTKKKRERIKKEL
Tt8511          FFDIDEEDQQKQKEKKHQNQSEGAPTVDLSKSIFSNSNYIHKDSRFSEGSESILSKSNMI
Tt8517          QGAQSELNNSSSSSQLSSSTRN--------------------------------------
Tt8516          KKAERQLDILNKSPSIQAPQADNKSVKSVDTVLTTQNSMND-------------------
Tt11012         ASIFNSILDESKSKNSFNSSSFHQSYGTSSKFESSSMN----------------------
Tt27559         -RLQTEDNQLQTLGPLINN-----------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         QNGKQNSQHHSNQQQQQNEFIDKLNNNNNAYN----------------------------
ScCCH1          -EYEDEKLDYLKKYPLFNYS----------------------------------------
20.m03897       LNARIVSYDIQRPDAIVDFIRFILVDEG--------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ---------------GPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVHIPV
CeEGL19         -------------------------------------------RMSEVP-----------
CeUNC2          --------------------------------------------EEESP-----------
DmCA1A          ----------------------------------------GPK-----------------
DmCA1D          ----------------------------------------RPRRMSEVN-----------
MmCACNA1D       ---------------------------------------PRPRRTSELN-----------
RnCAC1B         ---------------GSLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPV
MmCACNA1A       RRTPNN-------PGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPAC
CeCCA1          -----------------------------------RNEAKQNTFVRKLLK----------
MmCACNA1H       -----------------------------------DIEDSCCFRLHKVLEP---------
CeNCA1          -----------------------------------LFLVGRASQLREFCK----------
RnRB21          -----------------------------------LFIVGREHRFRNFCR----------
CeNCA2          -----------------------------------LFLVGRESSLRRMCQ----------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         LQEQNV-------KNNEKINYSNYNQVVHAINAPIKKQKNEQNEIQDNFDFKNEYLDQLR
Tt8511          DESNLNNTSNSITLEFSENQTSKKQAQENKTDSVFNTEFEKEPIEHDYVSTRKKEILNLE
Tt8517          ------------------------VLVKKTVEVFDMVAFQNEPVDLQFLQQRKKEIYNLE
Tt8516          --------------ENDANSTQKNIFQNQQVEAFDFEQFQQESAEYKYLQQRKKDIQNFE
Tt11012         ---------------SYSMKSQSKEGKSAFDETNADTASKRSKYSKNKDDTNSKAQDSNK
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         -------------------------------KNLGSNSFKELNMTSEQNEN---------
ScCCH1          -----------------------------------YYFFSPQHRFRRFCQR---------
20.m03897       ------------------------------LVDASKKTVVRASGSRRRGKPG--------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         MLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRF
CeEGL19         ----------------------------------AASTVKPIPKASSLFILSHTNSFRVF
CeUNC2          -----------------------------------FGGPKPMVPYSSMFFLSPTNPFRVL
DmCA1A          ----------------------------------------PMLPYSSMFILSPTNPIRRG
DmCA1D          ----------------------------------TATKILPIPPGTSFFLFSQTNRFRVF
MmCACNA1D       ----------------------------------MKEKIAPIPEGSAFFILSKTNPIRVG
RnCAC1B         TLTGPPGEATVVPSANTDLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRF
MmCACNA1A       PPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRL
CeCCA1          ------------------------------------KTCLHNRTEFSLFLMGPKNPLRIK
MmCACNA1H       ----------------------------------YAPQWCSSRESWALYLFPPQNRLRVS
CeNCA1          ---------------------------------KMVHSKYDSQDDGTNGGAKTKKRFKEI
RnRB21          ---------------------------------VVVRARFNASKTDPVTGAVKNTKYHQL
CeNCA2          ---------------------------------LIAHSRHSYDQNDGQ-HRKHSNKYKQF
NtTPC1A         ---------------------------------------------------LRLRTLKKA
AtTPC1          ---------------------------------------------------MKRRMLEKA
OsTPC1          ---------------------------------------------------TRKSILEKA
CfTPCN2         ---------------------------------------------------FQTSLFRRR
HsTPCN2         ---------------------------------------------------LQTSLFRRR
Tt10302         EDALTGIKTKQIFSGIDVLRGYRGGALRLNKVLRPLNSDRQEIKMWIPGILGILIVIHKH
Tt8511          KKGQNLIKVDWSGDAVIPSTIAIKEQKQLNLIISKLNISKYDMEQNEGGLIGIIQALRRR
Tt8517          KKGINQIKVQTSADDILWISLRNKNQKALNQVIDSLNYSSRIIEQNEGGFVGLVQAFRRR
Tt8516          KKGICELKVQTSADDVLSISLKYKQQDALSKVLDTINCRQDIIEQNEGGIIGIIQAIRRR
Tt11012         SKDGKEDKGNGENQDYFQKPQTLEQFLKEPLEKEYVQVVKQQVNNLIQKGQNKIKSYWSG
Tt27559         ------------------------------------QDQQTLKDFRSPGLNFKIMPLKND
Tt14193         -----------------------------------KFILRLSNYKLNIFQNKRYVLLMQY
Tt27255         ---------------------------------SHDINNDEEEEERSLFIFSKENKFRKI
ScCCH1          ---------------------------------LVPPSTGKRTDGSRFFEDSTDLYNKRS
20.m03897       ---------------------------------SMGDSSSASEIPDVGLEFFQGGRVSTF
583.m05406      -----------------------------------VAARLARPLLLALFYYPVIGMLLRI
Tg3277          ----------------------------------------VWADQDAAAAEFKKIAAARG
                                                                            

HsCAC1B         CHYIVTMRYFEVVILVVIALSSIALAAEDP-VRTDS-------------PRNNALKYLDY
CeEGL19         CNMVVNHSYFTNAVLFCILVSSAMLAAEDP-LQANS-------------TRNMILNYFDY
CeUNC2          IHSIVCTKYFEMMVMTVICLSSVSLAAEDP-VDEEN-------------PRNKVLQYMDY
DmCA1A          AHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENS-------------RRNKILNYFDY
DmCA1D          CHWLCNHSNFGNIILCCIMFSSAMLAAENP-LRAND-------------DLNKVLNKFDY
MmCACNA1D       CHKLINHHIFTNLILVFIMLSSAALAAEDP-IRSHS-------------FRNTILGYFDY
RnCAC1B         CHYIVTMRYFEMVILVVIALSSIALAAEDP-VRTDS-------------FRNNALKYMDY
MmCACNA1A       CHYILNLRYFEMCILMVIAMSSIALAAEDP-VQPNA-------------PRNNVLRYFDY
CeCCA1          CLQTTQKKWFDYTVLFFIGINCITLAMERPSIPPDS-------------FERQFLHISGY
MmCACNA1H       CQKVIAHKMFDHVVLVFIFLNCITIALERPDIDPGS-------------TERAFLSVSNY
CeNCA1          RALIGIMPYIDWAMATVTIVSCISMLFESPWPTTGENL----------VMNNGYLQISDY
RnRB21          YDLLGLVTYLDWVMITVTICSCISMMFESPFRR---------------VMHAPTLQIAEY
CeNCA2          HDFLAIMTYMDWTMVLVTTLSCCSMLWESPWPTTGENL----------IFNNFYLQIAEY
NtTPC1A         FSLIDE------------------------------------------------------
AtTPC1          FGLIDS------------------------------------------------------
OsTPC1          FGIIDA------------------------------------------------------
CfTPCN2         LGARAAYEVLS-------------------------------------------------
HsTPCN2         LGTRAAFEVLSS------------------------------------------------
Tt10302         INHFVKSSFFNNLATIAVFANTVVLALAGSFSDDQS---------------NQILDWLNN
Tt8511          IKYIVHSPIFEYSIMICVIINTIILSLDGIVTDTQG---------------LQTISQFNI
Tt8517          IRKLVTHQQFENLVMLFVLSNTIILCLDGIVPSSSS----------------ATLTQLNY
Tt8516          VKGFVMHPVFENLIMLCVLLNTVVLCMDGIIPTSSA----------------YILDTFNL
Tt11012         DDVLVATKVYKQQQAIKTLMKCLNYPNTITEQNEGGFMGIVNAFRRRVRMLVQTPLYENL
Tt27559         EIDEQKPRNANYPKPQKVNEVTSQLGEERTFQRQGS------------------NNNDST
Tt14193         CSRIENSPYFINFLIFLTVANTALLAAQSRLDDPNS-------------TKIKTLRALEM
Tt27255         CKNIVMHNYFDYFNSICIAALAFLFCADTPFVDPNS-------------SEQVVIIVFHA
ScCCH1          YFHHIERDVFVFIFALATILLIVCSCYVTPLYRMHHKMG-----------TWNWSSALDC
20.m03897       LRQVMNGTAYRWIVAGLDIASLACLVVECMLTDNYETR--------------KVFGVLEW
583.m05406      VRTLPKVRTIILAALLSVLLFDWLGVILFAGTSGHD--------------------EFNS
Tg3277          GNGLMTLHAFRLLVTIFVILDVLKFGASTYFPPSNYT-------------AFLVFLFLNL
                                                                            

HsCAC1B         IFTGVFTFEMVIKMIDLGLLLH----PGAYFRDLWNILDFIVVSGALVAFAFSGSK----
CeEGL19         FFTSVFTVEITLKVIVFGLVFH----KGSFCRNAFNLLDILVVAVSLTSFVLR-------
CeUNC2          CFTGVFACEMLLKLIDQGILLH----PGSYCRDFWNILDGIVVTCALFAFGFAGTEG--S
DmCA1A          AFTGVFTIEMLLKIVDLGVILH----PGSYLREFWNIMDAVVVICAAVSFGFDMSGS--S
DmCA1D          FFTAVFTIELILKLISYGFVLH----DGAFCRSAFNLLDLLVVCVSLISL------V--S
MmCACNA1D       AFTAIFTVEILLKMTTFGAFLH----KGAFCRNYFNLLDMLVVGVSLVSFG--------I
RnCAC1B         IFTGVFTFEMVIKMIDLGLLLH----PGAYFRDLWNILDFIVVSGALVAFAFSSFMGG-S
MmCACNA1A       VFTGVFTFEMVIKMIDLGLVLH----QGAYFRDLWNILDFIVVSGALVAFAFTGNSK---
CeCCA1          IFTVIFTGEMMMKVIANGCFIG----QAAYFKDGWNILDGILVVISLINIAFELLATG-D
MmCACNA1H       IFTAIFVVEMMVKVVALGLLWG----EHAYLQSSWNVLDGLLVLVSLVDIIVAVASAG--
CeNCA1          FFVLSMTFELCVKIIANGLFFT----PKAVVRDVGGVMNLFIYFTSVIFLAWMP-----K
RnRB21          VFVIFMSIELNLKIMADGLFFT----PTAVIRDFGGVMDIFIYLVSLIFLCWMP-----Q
CeNCA2          IFVLVMSFELIVKCIANGLFFT----PKALVTDVGDILTIFIYITSLMFLIWMP-----N
NtTPC1A         -----------------------------------------------------------A
AtTPC1          -----------------------------------------------------------D
OsTPC1          -----------------------------------------------------------T
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         FFTFVFIGEMAFKIIG----LT----PAGYVRDRMNIFDGFIVCLSILELVIFSGSGS-K
Tt8511          SFTFIFAIDMILKIIGDG--------FTEYVSDKMNIFDCIIVCLSLFELFFITETGSGS
Tt8517          IFTIIFAVDMGLKLIGLG--------FTEYVSDKMNIFDAIIVILSILELAVLSGSS---
Tt8516          IFTILFAIDMGLKIIGMG--------LVMYASDKMNIFDAVIVSLSIFELIFLNGTS---
Tt11012         IMIAVVMNTVILSLDGSVDSLG----FALYCADRMNIFDGLIVILSIFDIIFLSGSSGGS
Tt27559         PDQRKSPFQLSMSSFKQYNKHR----SQADLEKEKKILNFYFTVVFCVEAAIKIIAYG--
Tt14193         ITMVIYFFEALIKIIARGFLLNG---PNSYMRQFKNIYDLFLLITQIIS-----------
Tt27255         ILTAFFIIENIMQIIAYGFIFS-----PTSFIQRNWFFNSIDIITTVASFFYTVDFWP--
ScCCH1          AFIGAFSIEFIVKTVADGFIYS----PNAYLRNPWNFIDFCVLISMWINLIAYLK-----
20.m03897       VFACVFLLEALLRISAYGCCRGRCVALDSVATRTAFAVSLLSCILLIVNQVFFVIEGPDS
583.m05406      FQSGCISLLLVVTTVRLPQVLLR---GYTVHEVAVLFIVVFYLLTAVLLGLFAAAFYSAY
Tg3277          GVWLFFLAEAALKIRLLGFRRYMN-----SLFTFFDGFLLLIQSAALAVRFAIVLDPDGV
                                                                            

HsCAC1B         -GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNS-LKNVLNILIVYMLFMFIFAV
CeEGL19         -TDAMSVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVA-VKTIGNIMLVTFMLQFMFAI
CeUNC2          AGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNS-LKNVFNILIVYFLFQFIFAV
DmCA1A          AGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNS-LKNVVNILIVYILFQFIFSV
DmCA1D          SSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVA-VKTIGNIVLVTCLLQFMFAV
MmCACNA1D       QSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVA-IRTIGNIMIVTTLLQFMFAC
RnCAC1B         KGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNS-LKNVLNILIVYMLFMFIFAV
MmCACNA1A       -GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNS-LKNVFNILIVYMLFMFIFAV
CeCCA1          SPKIFGVIRVLRLLRALRPLRVINRAPGVKLVVMTLISS-LKPIGNIVLICCTFFIIFGI
MmCACNA1H       GAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISS-LRPIGNIVLICCAFFIIFGI
CeNCA1          HVEINSLAQFLMICRAMRPLRIYTLVPHIRRVVLEFFRG-FKEILLVTILMIVVMFIFAS
RnRB21          NVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSG-FKEIFLVSILLLTLMLVFAS
CeNCA2          HIEINSWAQLLMVCRAMRPLRVYALIPHIRRVVVELCRG-FREILLVTILLVVLMFIFAS
NtTPC1A         NNGHLNEKQCTLLFEELNKYRTLPKIS--GDDFKSIFSE-LDDTGDFKINLDEFADLCTA
AtTPC1          KNGEIDKNQCIKLFEQLTNYRTLPKIS--KEEFGLIFDE-LDDTRDFKINKDEFADLCQA
OsTPC1          GQGYLNKEQCLSLLDELNKYRSLPKTS--REDFELIFAE-LDQSGDFKVTSEEFATLCNT
CfTPCN2         KTAEGEAHPQRVGVKPQDFLQVLQKVQLDSAHKQAIVEK-VCSYGDDLLSADEFQKLFNE
HsTPCN2         MVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEK-VRSYGSVLLSAEEFQKLFNE
Tt10302         AFSAFRSVRIFRTFRVLRVTRLLRGLEFMGVIIKVISRT-LDSFIYIAFLLFLFIFIFTL
Tt8511          SFSAFRAIRILRVFRVLRVTRLVRSLQFMKLMITAIGSS-LSQFIYILLLLFLFMFIYTL
Tt8517          SVSAFRSLRILRVFRVLRVTRLLRSLQFMKVLIAAISST-LEQFIYILLLLFLIMFIYAL
Tt8516          SVSALRSIRILRVFRVLRVTRLLRSLQFMKILVTAISST-LEQFIYILLLLFLIMFIYAL
Tt11012         SFSAFRSLRILRVFRVLRVTRLLRSLKFMKILIKVISSI-LDKLFYIILLLILYIFIYTL
Tt27559         ----FLYNFTKPDQAYLRSPWNILDFFVNILLVNSLFQT-IPVLTSLAFVILIMTWIFAI
Tt14193         -LLVYPDYVIFRTLRTLNLFHLSKYFVGVRVMLVSLSQS-VPTILRLLLFTFCILIVFAI
Tt27255         -RSVYVFKFILILRLTVLFSFLSHQVKEVHHAGMILIKC-LPRMLRLIIFAAIFLLISGA
ScCCH1          --NNGNLSRIFKGLTALRALRCLTISNTARQTFNLVMFDGLNKIFEAGLISLSLLFPFTV
20.m03897       AITFVWQLPLFRVVKVLRSLRSFLLFSLVEMWGVRLVVRSLVACRRSLLILSAFLTLVYI
583.m05406      RDGDIADSRKQLALSSRYLNRAFNLLLASQEQCVGAPSPSSAASAKKFLLASEASFALGR
Tg3277          GKPVFDPGSVERDDSIVNEFMQSRIHVALLTLDTIQLCRVYRLTFSCRELFLLTKSILHS
                                                                            

HsCAC1B         IAVQLFKGKFFYCTDESKELE--RDCRGQY-----------LDYEKEE---VEAQPRQWK
CeEGL19         IGVQLFKGTFFLCNDLSKMTE--AECRGEY-----------IHYEDGDPTKPVSKKRVWS
CeUNC2          IAVQLFNGKFFFCTDKNRKFA--NTCHGQF-----------FVYDNQN-DPPRVEQREWR
DmCA1A          IGVQLFNGKFFYCTDESKHTS--AECQGSY-----------FKYEE-DELLPKQELRVWK
DmCA1D          IGVQLFKGKFFKCTDGSKMTQ--DECYGTY-----------LVYDDGDVHKPRLREREWS
MmCACNA1D       IGVQLFKGKFYRCTDEAKSNP--EECRGLF-----------ILYKDGDVDSPVVRERIWQ
RnCAC1B         IAVQLFKGKFFYCTDESKELE--RDCRGQY-----------LDYEKEE---VEAQPRQWK
MmCACNA1A       VAVQLFKGKFFHCTDESKEFE--RDCRGKY-----------LLYEKNE---VKARDREWK
CeCCA1          LGVQLFKGMMYHCIGPEVGNV--TTKADCI-----------EDYRN-----------KWV
MmCACNA1H       LGVQLFKGKFYYCEGTDTRNI--TTKAECH-----------AAHY------------RWV
CeNCA1          FGVQIVGGKLAACNDPTVSSR--ENCTGVFWQKLFVTRLEVYGKDTEAMHPKIMVPRVWT
RnRB21          FGVQLFAGKLAKCNDPNIIRR--EDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWA
CeNCA2          FGVQLVGGKLASCNDPMITSR--ENCTGLYDVKLFVTRMEVYGKNDNLMHPSIIVPRVWT
NtTPC1A         IGLRFQK-------EDSLPIF--EACPNFY------------------------------
AtTPC1          IALRFQK-------EEVPSLF--EHFPQIY------------------------------
OsTPC1          IAIKFQK-------EPPPSYL--EKYPSFY------------------------------
CfTPCN2         FDKRVIKEHPPRPEYGSPFLQ--SAQFLFS-------------------------HRYFD
HsTPCN2         LDRSVVKEHPPRPEYQSPFLQ--SAQFLFG-------------------------HYYFD
Tt10302         LGMQIYGGKLQIIDPRVRQNF--DNFQNGFITVFQLMTIENWNDILYKTFNSSVNKFLTS
Tt8511          LGMSLFGGSFNMPDKPTRMNF--DSFLNSAFAILQLLTIENWNTLLQICIRSNVSNYLSV
Tt8517          LGMNIFGGNWPTFNSNIPSRFNYDQFLNAYMAVLDLVTLENWNDQLTTCLLSNVSNYVCS
Tt8516          LGMSLFGGNWPVYNSNIPSRLNYDQFINAAFAVLDLLTLENWNDQLTNCLISNVSNYVCT
Tt11012         IGMQLYGGSFLSVSRSNRMVF--DSFLQASFSVYDLLTIENWNNILYVALRTQVNVGITC
Tt27559         FLMSSFKGELQYCSFDDINNMVDSDLYKKIVT-----------------IQDCNQSGGQW
Tt14193         IPMKQLKGKMYYCASLEREKLESIHSKQDCLD-----------------------EGGDW
Tt27255         LTTKLLKGSMHHCYIGDESDGENSEIPEIIT------------------KFDCLDLGGDW
ScCCH1          WGLSIFKGRLGTCNDGSLGRADCYNEYS-N-----------------SVFQWDIMSPRVY
20.m03897       IFALIFSRIIRVDYVPPEDPN---------------------------------------
583.m05406      DRPETETREQLSFQTWRAFYAHYAALSGRP------------------------------
Tg3277          LRSLQWTALFVFCVIYTCAIFCTWTFYDAD-----------------------------D
                                                                            

HsCAC1B         KYD-FHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFV
CeEGL19         NND-FNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALFFIAFII
CeUNC2          LRP-FNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFI
DmCA1A          PRA-FHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFI
DmCA1D          NNR-FHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYII
MmCACNA1D       NSD-FNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYII
RnCAC1B         KYD-FHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFV
MmCACNA1A       KYE-FHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFV
CeCCA1          NHR-YNFDNLGQALMSLFVLSSKDGWVSIMYQGIDAVGVDVQPIENYNEWRMIYFISFLL
MmCACNA1H       RRK-YNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLL
CeNCA1          NPRNFNFDHVGNAMLALFETLSFKGWNVIRDILWSRHG----------PWAVVFIHIYVF
RnRB21          NPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG----------PIHGIYIHVFVF
CeNCA2          NPRNFNFDHIGNAMLALFETLSYKGWNVVRDVLYLRHG----------AWAVLFIHIYVF
NtTPC1A         -------HSPASEKLRGFVRGA----------------------------------TFEY
AtTPC1          -------HSALSQQLRAFVRSP----------------------------------NFGY
OsTPC1          -------HSALCEWLKSFVRSP----------------------------------LFEY
CfTPCN2         YLG-----------------------------------------------------NFIA
HsTPCN2         YLG-----------------------------------------------------NLIA
Tt10302         IYLIVWIFIGNWIFLNLFLAILLDGFTDQSQEDSLALEDEDQYEEEVVDKNENKNQQFNQ
Tt8511          LFLISWMFIGNYIFMNLVLAIVMDSFDSAEVQADRREIENRFEVVEDIDFNYSSVGTTIL
Tt8517          AYLVSMIFIGNYILIDLVLAIMLDSFESDEVQKDRQEIENRFEIVQDITFGHTSMGSTFM
Tt8516          AYLISMIFIGNYILLGLVLAIMLDSFNSAEVQNDRQEIENRFEIVQDLTFGHTSMGTTFM
Tt11012         IYLISCIFIGNFIIMNLVLATMIGAFNSSQFDKEKEEIANTVEIVEDLDLGHTTTLNSTT
Tt27559         VNQYFNFDTVFLSVISLFKIILGENWTQLMWSSIDASGIEKQPIKDYQRGYALIYLLLLF
Tt14193         LNNLQNWDNVLFSLFNLFIMASCEGWSILMGQANDARGVDLNPQQNQEKEWSVYFIIYFI
Tt27255         IDSQYNFNNIINSLQILFMVQSSEGWIHIMFNVYDSTSPELNSHYRQNSLWAIFFIQFFF
ScCCH1          QQPYLHLDSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPATVMGSAGNALFLVLFNF
20.m03897       -EVAYTFRTFKDGWLGVFVLATNEGWPLLLAKVLDRSPTQR-------VTLTVLFFIFIS
583.m05406      -HSGPAGDRGETLELGGDSKTQNESRWSAASPALHAPLPPALVSSLVSAQLASPFLRLLS
Tg3277          AEMSLLWGNLILSMFTLFTVLTLEGWNGVANSTAEKHP-----------FSRIFFVCFIC
                                                                            

HsCAC1B         VFPFF------------------------------------------------FVNIFVA
CeEGL19         VIAFF------------------------------------------------MMNIFVG
CeUNC2          VFPFF------------------------------------------------FVNIFVA
DmCA1A          VFPFF------------------------------------------------FVNIFVA
DmCA1D          IIAFF------------------------------------------------MVNIFVG
MmCACNA1D       IVAFF------------------------------------------------MMNIFVG
RnCAC1B         VFPFF------------------------------------------------FVNIFVA
MmCACNA1A       VFPFF------------------------------------------------FVNIFVA
CeCCA1          LVGFF------------------------------------------------VLNMFVG
MmCACNA1H       IVSFF------------------------------------------------VLNMFVG
CeNCA1          IGCMI------------------------------------------------GLTLFVG
RnRB21          LGCMI------------------------------------------------GLTLFVG
CeNCA2          IGCMI------------------------------------------------GLTLFVG
NtTPC1A         IIVFV------------------------------------------------LLVNLVA
AtTPC1          AISFI------------------------------------------------LIINFIA
OsTPC1          IVIFV------------------------------------------------LLMNLVA
CfTPCN2         LGNLV------------------------------------------------SVSVFLV
HsTPCN2         LANLV------------------------------------------------SICVFLV
Tt10302         LNQEN------------------------------------------------LQILNED
Tt8511          AQTSQ------------------------------------------------FSSSGYS
Tt8517          NNLSQSNYASS-------------------NNMNRISTGLQNSSLHNSGGIQRSATLSKQ
Tt8516          NNLSQSMGNQS-------------------SNNMSRISG--GIQQSGGLQRSATLSRQVI
Tt11012         FMNMSNSQSRLGSSTHSFSVKNRQRMLSSGGSSQGYSDEHSQNNHSQHSFSKKSQQIQKE
Tt27559         MGNIF------------------------------------------------TTNLITG
Tt14193         LGNIM------------------------------------------------LFNAFTG
Tt27255         IANIC------------------------------------------------ILNMFVG
ScCCH1          LSMVF------------------------------------------------ILNLFVS
20.m03897       TVSIF------------------------------------------------AVKMCVG
583.m05406      SPSSD-------------------------------------------------SGIGEA
Tg3277          FTTLT------------------------------------------------LLNIVTG
                                                                            

HsCAC1B         LIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQ---------------
CeEGL19         FVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNR----------------
CeUNC2          LIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKN---------------
DmCA1A          LIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRN---------------
DmCA1D          FVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHG----------------
MmCACNA1D       FVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNP----------------
RnCAC1B         LIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQ---------------
MmCACNA1A       LIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQ---------------
CeCCA1          VVVENFHKCKEALEKEMREKEKEKRLKRKLKRQKFEESMAGKRKKMERNYPY--------
MmCACNA1H       VVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPNPEAQRR-----PY--------
CeNCA1          VVIANYTQNRGTALLTVDQRRWHDLKARLKMAQPLHVPPKPSESAR--------------
RnRB21          VVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRP-DNDG--------------
CeNCA2          VVVANYTENRGTALLTVDQRRWHDLKARLKMAQPLHVPPKPPESAK--------------
NtTPC1A         VIIETTLDIQNNSGQT--------------------------------------------
AtTPC1          VVVETTLDIEESSAQK--------------------------------------------
OsTPC1          VIIETTLDIENSSSQK--------------------------------------------
CfTPCN2         MDADVLPEDRDD------------------------------------------------
HsTPCN2         LDADVLPAERDD------------------------------------------------
Tt10302         FERMDSEEMELIEQEILQLEGKSQNQQLFIGIECSHSLYLFSKQNS--------------
Tt8511          NSLMNKINSNSFSNSHRKSQTDSQSMHSQTLKSGSQNQIEDEDLEEVKRENINQVQ----
Tt8517          AILKTSSQNDSGQFEKQKSVNGDDDSVSEKGGIASEQNLQDTGPKKKNQFQYYEG-----
Tt8516          NKLSQSNDSGQLDKSKSIIGGDDHSSSDRVTSINSESKLKQDNKKNKNKFIWFEG-----
Tt11012         SFSREYKEKASSISDSHNQSLDNKSSHNLELQIVSEQEQNNDKNNQKNMFKQQAVVKKDE
Tt27559         LVVNNFKRIKDEISGYKNLTSIQRQWVEMQKYMMKRKLKVVIPTPEN-------------
Tt14193         VMIEKYIEIKKKFALQQEIVHVKDATKLERQSTKIRFDLHQHIDAGDEVVEWMEIKKSIY
Tt27255         LVVETQLEMIESEHKTKDLHKFQKEWLFIKKSIYQLKPSAKVKIPQDK------------
ScCCH1          FIVNNQARTTGSAYFTIEEKAWLESQKLLSQAKPKAIPNLIELSRVR-------------
20.m03897       IIVDASRRKKARMEMEGSLLSATVHKWIEIQELLFNAPLQHGDTMPDFTNADSKK-----
583.m05406      ETDGETGDKVRRKTREAAEDGSFQDSPDDAQAAVEEKPNEPSAAFLPS------------
Tg3277          IILDAYVDMSSRLAAEASYHEHLEKDAR--------------------------------
                                                                            

HsCAC1B         ---------------------------SFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMK
CeEGL19         ----------------------------LQYRVWWFVTSRAFEYVIFLIIVMNTVSLACK
CeUNC2          ---------------------------STKYRIWRLVTSPPFEYFIMTMICCNTLILMMK
DmCA1A          ---------------------------TFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMK
DmCA1D          ----------------------------IQYKVWWFVTSSSFEYTIFILIMINTVTLAMK
MmCACNA1D       ----------------------------YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQ
RnCAC1B         ---------------------------SFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMK
MmCACNA1A       ---------------------------SFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMK
CeCCA1          ----------------------YHDYGHTRLFLHGIVTSKYFDLAIAAVIGINVISMAME
MmCACNA1H       ----------------------YADYSHTRRSIHSLCTSHYLDLFITFIICLNVITMSME
CeNCA1          ----------------------------LRTKLYDLTMSRWFNQAFALLVVLNSFTLVIP
RnRB21          ----------------------------FRAKMYDITQHPFFKRTIALLVLAQSVLLSVK
CeNCA2          ----------------------------LRCYLYDLTTSRWFKQLFAVLVVVNSFTLVIP
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ----------------------------IRILFYKIVKHPQFENLILFFIVTSSLKLVVD
Tt8511          -------FIYFAGVKCQQSLYIFSQQNIIRKICYRALVHPLFEQVVLMVIVLSSIKLTMD
Tt8517          -------------VECEQSLYIFSKDNIIRKTLYYVYKNPLFDKVVLLVIILTSFKLTFD
Tt8516          --------------------VECEKSLFLFSKEGNFRKSIYYIYKHAIIIILTSFKLTFD
Tt11012         DDEKEEIFLFFDNIKCQKSLYIFSMQNKIRRAFYFIVKNPLFDNIILAGIILNSVKLVSD
Tt27559         ---------------------------TYRHFCYILAKSSKFEKIIIFFIILNLVTMGCQ
Tt14193         DTR--APKVQSFTLLIKKYSKPTKEQDYLRHYLYILINHKHYKMCMDTCIILSTICFALN
Tt27255         ---------------------------VRKFLFDNLIQGNALKIIFYTFTLANCINLMLF
ScCCH1          ---------------------------QFFYQLAVEKKNFYYASFLQVVLYLHIIMLLSR
20.m03897       -------------------------VAFVRKKLAAIVTSEWFRIVVALHTCICCLLLFLY
583.m05406      ---------------------------QRLPSEQSLTRDTEVYGTGQTLSTISCLPRASP
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         FYDAPYE-------YELMLKCLNIVFTSMFSMECVLKIIAFGVLN----YFRDAWNVFDF
CeEGL19         HYPSSRG-------FEDFLDVFNLIFTGVFAFEAVLKIVALNPKN----YISDRWNVFDL
CeUNC2          YYNNPLF-------YEEILRLFNTALTAVFTVESILKILAFGVRN----YFRDGWNRFDF
DmCA1A          YHNQGDM-------YEKSLKYINMGFTGMFSVETVLKIIGFGVKN----FFKDPWNIFDL
DmCA1D          FYNQPLW-------YTELLDALNMIFTAVFALEFVFKLAAFRFKN----YFGDAWNVFDF
MmCACNA1D       HYEQSKM-------FNDAMDILNMVFTGVFTVEMVLKVIAFKPKG----YFSDAWNTFDS
RnCAC1B         FYDAPYE-------YELMLKCLNIVFTSMFSLECILKIIAFGVLN----YFRDAWNVFDF
MmCACNA1A       FYGASVA-------YENALRVFNIVFTSLFSLECVLKVMAFGILN----YFRDAWNIFDF
CeCCA1          FYMMPMG-------LKYVLKALNYFFTAVFTLEAAMKLIALGFKR----FFIEKWNRLDM
MmCACNA1H       HYNQPKS-------LDEALKYCNYVFTIVFVFEAALKLVAFGFRR----FFKDRWNQLDL
CeNCA1          WNVEEEEQR---ATYVFTVTALAAFMNMLFVIEIILKVIAYTFSG----FWQSRRNRVDL
RnRB21          WDVEDP--------VTVPLATMSVVFTFIFVLEVTMKIIAMSPAG----FWQSRRNRYDL
CeNCA2          WNVSEEQDR---KTFLLCLTVISAICNILFTLECLLKMIAFTLSG----FWQSRRNRIDF
NtTPC1A         -----------------FWQKVEFTFGWLYVIEMALKVYTYGFEN----YWRDGQNRFDF
AtTPC1          -----------------PWQVAEFVFGWIYVLEMALKIYTYGFEN----YWREGANRFDF
OsTPC1          -----------------VWQEVEFVFGWIYVIEMALKIFSLGFGA----YWMEGQNKFDF
CfTPCN2         ----------------FVLGILNCVFILYYVLELLLKVFALGLPG----YLSYSSNLFDG
HsTPCN2         ----------------FILGILNCVFIVYYLLEMLLKVFALGLRG----YLSYPSNVFDG
Tt10302         TYVDEHS------DVGIALKNVDLMFNFIFIAEATLKIISFGFIGDENSYLDESWSQIDF
Tt8511          TYVNDQES-----QIYIVGLSIDKFFTAFFALESLIKIISLGLVLDDNSYLRDSWSQLDF
Tt8517          TYIGSADVG-----ATKFSNNADLFFTIFFICECVVKVVSLGFFLDEGSYLRDSWSQLDF
Tt8516          TYIGTADVT-----ATQFSNDADLFFTIFFLCECLIKVIALGFILDEGSYLRDNWCQLDF
Tt11012         TYDTGSDS------QKQASQILDIMFTVFFSIESCLKIVSYGFFFDENSYLRDNWSKLDF
Tt27559         YKGMDDQG-------AYAINVINNFCLGIYHVEALIKIVGVGVYF----YFKDDWNKFDF
Tt14193         YWRAP----------DLYEQILRNLFLIIYIIEIGLKIYTEKFLF-----FASRFQIFEL
Tt27255         RNRQTQEE-------IDKLYLVNEVCLVAMIIEIFCRMVCLNLKY-----FTEPWNVIDL
ScCCH1          SYNPGNLIG--------YQGVYFMFSTSVFLIQEALHMCGEGPRL----YFRQKWNSIRL
20.m03897       GPWYDLTLGPYHQNRRVYLHIALVGMSLFFFFEIGVKIFVRGQLF-----FRDTLDIMDA
583.m05406      LSASPSTSS------QGALATTGTIPTLQMSGETVSSREEKPSRE-------EEGEEGDE
Tg3277          ---------------NEDLLTKAFQQTEFLFSLPASAAATSGFRN---------WTSLSR
                                                                            

HsCAC1B         VTVLGSITDILVTEIAETN----------------------NFINLSFLRLFRAARLIKL
CeEGL19         LVVVGSFIDITYGKLNPGGT---------------------NLISINFFRLFRVMRLVKL
CeUNC2          VTVVGSITDALVTEF---GG---------------------HFVSLGFLRLFRAARLIRL
DmCA1A          ITVLGSIVDALWMEFGHDD---------------------SNSINVGFLRLFRAARLIKL
DmCA1D          IIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKL
MmCACNA1D       LIVIGSIIDVALSEADNSEE--------------------SNRISITFFRLFRVMRLVKL
RnCAC1B         VTVLGSITDILVTEIAN------------------------NFINLSFLRLFRAARLIKL
MmCACNA1A       VTVLGSITDILVTEFGN------------------------NFINLSFLRLFRAARLIKL
CeCCA1          FIVILSIAGIIFEEFEA-LELP------------------INPTIIRVMRVLRIARVLKL
MmCACNA1H       AIVLLSIMGIALEEIEMNAALP------------------INPTIIRIMRVLRIARVLKL
CeNCA1          LITVFGVIWIFLHFFVALPSSKIDV----------DVQVELKKFTYTFGYLVVILRFFTI
RnRB21          LVTSLGVVWVVLHFALLN------------------------AYTYMMGACVIVFRFFSI
CeNCA2          IITILGINWIVFHFLFQLPAYFAG------------GITEWKRLTYTYGYLVVILRFFTI
NtTPC1A         VVTWVIVIGETATFVAPDGLTFLS-----------------NGEWIRYLLIARMLRLIRL
AtTPC1          LVTWVIVIGETATFITPDENTFFS-----------------NGEWIRYLLLARMLRLIRL
OsTPC1          VLTWTIFIGETLTFAFPSKLSFLS-----------------NGEWIRYLLLGRMLRLTRI
CfTPCN2         LLTVVLLVLEISTLAVYRFPHPGWKPEMLG--------LLSLWDMARLVNMLIVFRFLRI
HsTPCN2         LLTVVLLVLEISTLAVYRLPHPGWRPEMVG--------LLSLWDMTRMLNMLIVFRFLRI
Tt10302         FIVCTSIIDMTFSGVN--------------------------VSFIKILRLLRTLRPLRF
Tt8511          FIVICSIIDVSVTSIN--------------------------LSAIKILRLLRTLRPLRL
Tt8517          FIVISSIIDLSLSQIDLG--------------------------AIKILRLLRTLRPLRL
Tt8516          FIVVSSLVDLSLSSVN--------------------------LNAIKILRLLRTLRPLRL
Tt11012         FVVVTSIIDVSLQNGN--------------------------FASLKILRLLRTLRPLRV
Tt27559         GVILITDIVLFSSIFVS------------------------TSTVSNLPIIFRALRLGRI
Tt14193         IMVSLSLVYLIMQGTLDMKDFKIH-----------------HREIVLCMEFISVFRVLRL
Tt27255         SIVIIGWINLRFQQTNEFEIFDRG-----------------LRIFDGVAKGLQLLRFYRI
ScCCH1          SIIIIAFIMNAVAFHVPAS----------------------HYWFHNIKGFFLLVIFLFI
20.m03897       IVCCLLIGIFVVDVVWWTLWRLP-----------------LESLTFWLLSFRLFRVARFL
583.m05406      VAALLSGRERGDNKVDGGDEQMVE------------------GGNWKAPKWRGVLAFFFG
Tg3277          SSGEGNKLSLDSGGPKK-----------------------------VPEAGSSDREKGEE
                                                                            

HsCAC1B         LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG-NIALD---------D
CeEGL19         LSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFG-KVALD---------D
CeUNC2          LQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFG-NIWLN---------A
DmCA1A          LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG-NIKLGT--------V
DmCA1D          LSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFG-KIALD---------G
MmCACNA1D       LSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFG-KVAMR---------D
RnCAC1B         CRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG-NIALD---------D
MmCACNA1A       LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG-NIGIDGE-DEDSDED
CeCCA1          LKMAKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFG-KLECSE------DHP
MmCACNA1H       LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG-RLECSE------DNP
CeNCA1          ASRNSTLKMLMLTVIMSMFRSFFIITALFLLVLFYAYTGVILFP-MVKYG----------
RnRB21          CGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFG-TVKYG----------
CeNCA2          AGRKSTLKMLMLTVVMSMVRSSFIIAAMFLLVLFYANAGVVLFG-MVKYG----------
NtTPC1A         LMHVERYRAFVATFFTLIPSLVPYLGTIFCILCFYCSLGLQIFG-GIVNTGNPNLAQTDL
AtTPC1          LMNVQRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVFG-GLVNAGNKKLFETEL
OsTPC1          LLQVRRFRAFVATFFTLMSSLMPYLGIVFCTLCIYCSLGLQIFG-GIVYAGNPTLEETDL
CfTPCN2         IPSMKLMAVVASTILDLIKNMRAFGGILVVVYYVFAIMGINLFR-GVVVAPPGNGSLAPD
HsTPCN2         IPSMKPMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR-GVIVALPGNSSLAPA
Tt10302         ISHNVNMKVVVIALFESISGIFNILIVIFLIWIMFAILGISLIGNRMGYCSGISYIYHVN
Tt8511          LNHNKSMKLIVTALMESVGGITNMIMVLILIWLMFAILALNLMKGKMHYCNGPDDLSLNL
Tt8517          LSQNKSMKLIVTALLQSMEGIANMIFVVLLIWLMFAILAMNLMGGKLFYCNTTGAVLQSS
Tt8516          LSQNKSMKLIVTALMESIGGIANMIIVVLLIWLMFAILGLNLMQGKLFYCNTTGAALSGS
Tt11012         LHHNKSMKLIVTTLLESIVGILNMLLVIFLVWLMFAILGVSLMGGKLQYCNFPNNGISYN
Tt27559         VKY-----VLIDSIYYLLPSLINIAFLVFLIAFICAILGMNLFSQVQLLDGDQQYPFFDS
Tt14193         AKTITIVKKTLNILFYILPEIAPVAGLLLYLIYMYALIGMQIFP------------FIKV
Tt27255         MKHFTIIKKLFKSLQYAISSIFGIFQVLIIFLFISVLISMNLFP------------YIKE
ScCCH1          IPQNDTLTELLETAMASLPPILSLTYTWGVLFLVYAIALNQIFG------------LTRL
20.m03897       YRQMPFFQTLFTTICRVMKSFLNVLTLLCLSIFFFAMWGVVLFN------------DAPV
583.m05406      KRKDAAASSNFTGKAVCLSGQRGLASSRLGANNVLAGGGEETELFSLLQRG-----AGDN
Tg3277          RRSQAFARASTGTFFSPAHAEPDREASAASAFFVEGDRTFQTVG--------------QC
                                                                            

HsCAC1B         DTSINR---------------------------------HNNFRTFLQALMLLFRSATGE
CeEGL19         STSIHR---------------------------------NNNFHSFPAAILVLFRSATGE
CeUNC2          ATEINR---------------------------------HNNFQSFFNAVILLFRCATGE
DmCA1A          ENSITR---------------------------------HNNFQSFIQGVMLLFRCATGE
DmCA1D          GNAITA---------------------------------NNNFQTFQQAVLVLFRSATGE
MmCACNA1D       NNQINR---------------------------------NNNFQTFPQAVLLLFRCATGE
RnCAC1B         GTSINR---------------------------------HNNFRTFLQALMLLFRSATGE
MmCACNA1A       EFQITE---------------------------------HNNFRTFFQALMLLFRSATGE
CeCCA1          CDGLGE---------------------------------HAHFKNFGMAFLTLFRIATGD
MmCACNA1H       CEGLSR---------------------------------HATFTNFGMAFLTLFRVSTGD
CeNCA1          -MAVSK---------------------------------HVNFRTASEALVVLFRCLTGE
RnRB21          -ENINR---------------------------------HANFSSAGKAITVLFRIVTGE
CeNCA2          -QAVGK---------------------------------HVNFRNGREALVVLFRSVTGE
NtTPC1A         AGNDYL---------------------------------LFNFNDYPNGMVTLFNILVMG
AtTPC1          AEDDYL---------------------------------LFTFNDYPNGMVTLFNLLVMG
OsTPC1          FSNDYL---------------------------------LFNFNDYPSGMVTLFNLLVMG
CfTPCN2         NSSAPCGSFEQL------------------------EYWANNFDDFAAALITLWNVMVVN
HsTPCN2         NGSAPCGSFEQL------------------------EYWANNFDDFAAALVTLWNLMVVN
Tt10302         QDRVNS------------------------------IFSNLSILTNEIPKQSSAKVWDTN
Tt8511          YAYNKQKCLNIPGAT--------------------WEIYDINCDNIGSSMLFLFILSSFE
Tt8517          YNVYQYPYEKCMKLPGA-----------------FWDRYPNNNDNIGFSMVMLFELSTFE
Tt8516          YNVYNYPKKQILKYIKNGFSFLTHQIKCEQLPGAFWDRYPNNSDNIGFSMVMLFVLSTFE
Tt11012         IYKYNQSQCSRVGG--------------------SWQTYDLNFDNVPAALLNLFVISTFE
Tt27559         RAPYPY---------------------------------SYNFQTFTGSFLVILQCIQNQ
Tt14193         QNTLNG--------------------------------YDQHFKTFNTAVFTLIRVASGE
Tt27255         QKIING--------------------------------YDVTFRDFPNALFTLIRVMTSE
ScCCH1          GSNTTD---------------------------------NINFRTVIKSMIVLFRCSFGE
20.m03897       EKYFNR---------------------------------HVNFKALTRAMMALVGSCTGE
583.m05406      ASGLAR----------------------------------SQFAQLVSTLAAYDAAKQKE
Tg3277          GSSAGR---------------------------------GAKLERKTTGLTSECSTTARP
                                                                            

HsCAC1B         AWHEIMLSC----------L---SNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNL
CeEGL19         AWQDIMLSCSDREDVRCDPM---SDDYHKGGLNESRCGNNFAYPYFISFFMLCSFLVINL
CeUNC2          GWQDIMMAAVQGKD---CAR---AGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNL
DmCA1A          AWPNIMLACLKGKACD-------DDA-EKAPGE--YCGSTLAYAYFVSFIFFCSFLMLNL
DmCA1D          AWQEIMMSCSAQPDVK-------CDMNSDTPGE--PCGSSIAYPYFISFYVLCSFLIINL
MmCACNA1D       AWQEIMLACLPGKLCD-------PDS-DYNPGEEYTCGSNFAIVYFISFYMLCAFLIINL
RnCAC1B         AWHEIMLSCLG-------------NRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNL
MmCACNA1A       AWHNIMLSCLSGKPCD-----------KNSGILTADCGNEFAYFYFVSFIFLCSFLMLNL
CeCCA1          NWNGIMKDALRDDCDS-----------SDHCETNCCVDPILAPCFFVIFVLISQFVLVNV
MmCACNA1H       NWNGIMKDTLRECTRE-----------DKHCLS---YLPALSPVYFVTFVLVAQFVLVNV
CeNCA1          DWNDIMHDCMRSAPFCY-------WNEGMNYWETDCGNFYGAIIYFCSFYLIITYIVRNL
RnRB21          DWNKIMHDCMVQPPFCT-------PDE-FTYWATDCGNYAGALMYFCSFYVIIAYIMLNL
CeNCA2          DWNDIMHDCMRAPPFCN-------WHPGLSYWQTDCGNYVGAIVYFCSFYLIITYIVLNL
NtTPC1A         NWQVWMQSYKELT------------------------GTAWTYAYFVSFYLISVLWLLNL
AtTPC1          NWQVWMESYKDLT------------------------GTWWSITYFVSFYVITILLLLNL
OsTPC1          NWQAWMESYRQLT------------------------GSYWSLIYFVSFYLISVLLLLNL
CfTPCN2         NWQVFLDAYRRYSG-------------------------PWSKLYFVLWWLVSSVIWVNL
HsTPCN2         NWQVFLDAYRRYSG-------------------------PWSKIYFVLWWLVSSVIWVNL
Tt10302         GWPDLMYQAIDSNTADVG---------------PVKDNYIQISYFYMIFILVGSFFLINL
Tt8511          GWPDYVWSFIDGGDDG-----------------PILNNSAYFAFFFAVFIFVGGFFSINL
Tt8517          GWPNYFWYYMDGSDTG-----------------PVWNNSKYFSLFFAAFIFVGSFFSINL
Tt8516          GWPNYVWYYLDGSDTG-----------------PVWNNSRYFGVFFTVFIFVGSFFSINL
Tt11012         GWPAYVFNYLDGSSDG-----------------PVYFGSAYFSIYIVFFILVGSFFSIDL
Tt27559         NWDWYIQQYGFDQSGCYS-----QSYSDQQQDGIKGCSNPLSYPFFLVVVFFLRYIIINL
Tt14193         QWFYVVNDAVRQQQPNFVCQT-ISNYDDYINNGLNGCGTYWGYIYFFSFHLFVSVIILNL
Tt27255         YWYVVAQEGAKKMQPDFVCFENIILYEDYQKYGQNACGSRLSYIFFYGFYLVFTLVILNI
ScCCH1          GWNYIMADLTVSEPYCSS---------DDNSTYTDCGSETYAYLLLMSWNIISMYIFVNM
20.m03897       DWHMILQQLRMYYTTTG-----------------QNFLAYLVIFFFICFIILVFFILMDL
583.m05406      EQRLWRSDSCRFALHRR----------------LLNVAADVCVVASLILTYMQTRKFIRK
Tg3277          PTEGNDGSNAGSGEGAE----------------KGEKTDKCDRDEKGERGEDRGCAPRKA
                                                                            

HsCAC1B         FVAVIMDNFE--Y-LTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPP
CeEGL19         FVAVIMDNFD--Y-LTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPP
CeUNC2          FVAVIMDNFD--Y-LTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAPP
DmCA1A          FVAVIMDNFD--Y-LTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPP
DmCA1D          FVAVIMDNFD--Y-LTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPP
MmCACNA1D       FVAVIMDNFD--Y-LTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP
RnCAC1B         FVAVIMDNFE--Y-LTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPP
MmCACNA1A       FVAVIMDNFE--Y-LTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPP
CeCCA1          VVAVLMKHLE--E-SNKRD---------------------AEG-PAEPTGENIENEITKS
MmCACNA1H       VVAVLMKHLE--E-SNKEAREDAEMDAEIEL-------EIAQGSTAQPPSTAQESQGTDP
CeNCA1          LVAVIMENFSLFY-SSEEDALLSYADIRNFQYVWNMVDQEQKRTIPVERVKFLLRLLKGR
RnRB21          LVAIIVENFSLFY-STEEDQLLSYNDLRHFQIIWNMVD-DNERCDPTFRVKFLLRLLRGR
CeNCA2          LVAIIMENFSLFY-SSEEDALLSYADIRNFQLVWNMVDIEQKRSIPVRRVKFLLRLLKGR
NtTPC1A         IVAFVLEAFQ------------------------AEVDLEASARCVDGDDKEAKSERRRN
AtTPC1          VVAFVLEAFF------------------------TELDLEEEEKCQ-GQDSQEKRNRRRS
OsTPC1          IVAFVLEAFF------------------------AEMELEKDGEADIQDPTLEGRNRRRS
CfTPCN2         FLALILEHFL-----------------------------------HKWDRRTHLQSLAGD
HsTPCN2         FLALILENFL-----------------------------------HKWDPRSHLQPLAGT
Tt10302         FVGVIFLNFN----EAQKNERQSSLFLTEEQKRWIEFQQMIIGVKAEFAQSVVPTQKIPK
Tt8511          FSAIMSFNFD------IAQKKAKNKYLTDEQSQWIELQRMIVKSTPDFNALKKPTNKIRF
Tt8517          FTAIISFNFD-IA-SKKAKNAYLTDEQSQWIELQRLIVRSTPDFTSMKPPSNFFRKFVNI
Tt8516          FTAIISFNFD------IATKKAKNAFLTDDQSQWIELQRLIVKSTPDYASMKPPDNNFRK
Tt11012         FGAVLSFHYD----IALQKIETRLQLYLSPNKQIQKIRNIVSMALSYDTSPSSYDTILQD
Tt27559         FLALVIEGFFD-T-LKENEAVISPEVLESIIEKWSVYDQNGTGFIDPEEMYLLLLDIPEP
Tt14193         FIAVLLELIIG------QNTAMSKYQLSKIKELWSEYDKQGYGFINYEDFWEFSFRIAML
Tt27255         FIATIIESYK-EA-FSADESAVNHYQLDDVLELWKQYDPEGKGYISYKEFWQFSSQIAII
ScCCH1          FVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSYLPRIMHSFDGP
20.m03897       FTAAVLDEYMD--TVKDENLWKISHQHRILIERWNPKNEPGNNYKSLDDMVELLSTIDHP
583.m05406      ASTLSGEEIESSP-VDLAEGLPASCFGSVAGAYWIQNALSFVYLVSVVVRIRVTSSIQRY
Tg3277          QETCGVEKGGGDGDGQGPGSLEETEDEERRRERRSTLDGDSSGDAHEDSQAWNEKDRKPK
                                                                            

HsCAC1B         LGLGKKCPARVAYKRLVRMNM-----------------PISNEDMTVHFTSTLMALIRTA
CeEGL19         LGFGKLCPHRLACKRLVSMNM-----------------PLNS-DGTVCFNATLFALVRTN
CeUNC2          VGFGKKCPYRLAYKHLIRMNM-----------------PVAE-DGTVHFTTTLFALIRES
DmCA1A          LGFGNKCPNRLAYKKLIRMNM-----------------PLDD-ELRVQFTTTLFALIREN
DmCA1D          LGFGKLCPHRMACKRLVSMNM-----------------PLNS-DGTVLFNATLFAVVRTS
MmCACNA1D       LGFGKLCPHRVACKRLVAMNM-----------------PLNS-DGTVMFNATLFALVRTA
RnCAC1B         LGLGKKCPARVAYKRLVRMNM-----------------PISNEDMTVHFTSTLMALIRTA
MmCACNA1A       LGLGKKCPHRVACKRLLRMDL-----------------PVAD-DNTVHFNSTLMALIRTA
CeCCA1          D---------------------------------------------------DDEIVEEH
MmCACNA1H       DTPNLLVVRKVSVSRMLSL-------------------------------PNDSYMFRPV
CeNCA1          LEVD----------------------------------------------PEKDRILFKH
RnRB21          LEVD----------------------------------------------LDKDKLLFKH
CeNCA2          LEVN----------------------------------------------DESDGLLFKH
NtTPC1A         VGTKTR-------------------------------------------SQRVDFLLHHM
AtTPC1          AGSKSR-------------------------------------------SQRVDTLLHHM
OsTPC1          VRVRTK-------------------------------------------GTMVDILLHHM
CfTPCN2         QETS--------------------------------------------YQMSVELLFRDV
HsTPCN2         PEAT--------------------------------------------YQMTVELLFRDI
Tt10302         LMYNIVTNQKFEIFIMVLIVCNILTMAMAYEGSPSSYDSILENINLFFTSCFILETIMKF
Tt8511          MLWSFVRSSYVEIFIIFCILCNIVTMAMAYDTSPQQYDQILNDLNIFFTSVFVTEAIIKI
Tt8517          LKLFSRQFENKQLQNVVMENRNVIVMAMTYDTSPQSFDQILSNINLAFTSVFIAESICKI
Tt8516          ILWRISESPKLDIFIIFCIIG----------------NVVVMAMAYDTSSSNYDFILQSV
Tt11012         INLGFS-------------------------------------------IVFITECLLKL
Tt27559         IGLKN-----------------------------------------------------EF
Tt14193         YGVDEADIS----------------------------------------NPVQKKNFLKF
Tt27255         YGVKSEDLMDIQNKNEFLKTLN---------------------------IPIFEDPINKV
ScCCH1          LSFKIWEG-----------------------------------------RLTIKSLVENY
20.m03897       IGIKHRYHPGEKRKTILAYIAKYG-----------------------LPIHEGSRVHLRD
583.m05406      TGFSLRERFDIVVGG----------------------------------SVMILELACLW
Tg3277          QSGAAR-------------------------------------------------FLRRV
                                                                            

HsCAC1B         LEIKLAPAGTKQHQCDAELRKEISVVWANLPQK-TLDLLVPPH---KPDEMTVGKVYAAL
CeEGL19         LKIYTEGN---IDEANEQLRSAIKRIWKRTHKD-LLDEVVPPAG--KEDDVTVGKFYATF
CeUNC2          LSIKMRPV-EEMDEADEELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGL
DmCA1A          LSIKMRAP-EEMDQADMELRETITNIWPLQAKK-MLNLLVPPSDQLNKGKLSVGKIYAGF
DmCA1D          LSIKTDG---NIDDANSELRATIKQIWKRTNPK-LLDQVVPPPG--NDDEVTVGKFYATY
MmCACNA1D       LKIKTEG---NLEQANEELRAVIKKIWKKTSMK-LLDQVVPPAG---DDEVTVGKFYATF
RnCAC1B         LEIKLAPAGTKQHQCDAELRKEISSVWANLPQK-TLDLLVPPHK---PDEMTVGKVYAAL
MmCACNA1A       LDIKIAKGGADKQQMDAELRKEMMAIWPNLSQK-TLDLLVTPHK---STDLTVGKIYAAM
CeCCA1          EPLAIEHVKEGELDEEEETEEGPTT-------------QIPDGHG---GIKRLSMQVLEQ
MmCACNA1H       APAAAPHSHP-LQEVEMETYTGPVTSAHSPSLEPRTSFQVPSAAS---SPARASDPLCAL
CeNCA1          MCYEMERLHNGEEVSFHDVLYMLSYRSVDIRKSLQLEELLQREELEFIIEEEVAKQTIRT
RnRB21          MCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRM
CeNCA2          MCHEMERLHNGDDVSFHDVLNMLSYRSVDIRKSLQLEELLQREELEYIIEEEVAKHTIRA
NtTPC1A         LRSELT--ECSNENP---------------------------------------------
AtTPC1          LGDELSKPECSTSDT---------------------------------------------
OsTPC1          LSNELD--GSQNRDQ---------------------------------------------
CfTPCN2         LEEPTEEELVEKLSHHPHLQLCR-------------------------------------
HsTPCN2         LEEPEEDELTERLSQHPHLWLCR-------------------------------------
Tt10302         IAFGIKGFFANDWNKFDLFVVVSSIVDIILNYSGALSASFLRIGPQLIRIIRVFRVSRLL
Tt8511          IAFGLQGYFFNGWNQFDFFVVCASIVDIVTTSMGRQFISFLRAGPQIARVLRVMRVSRLL
Tt8517          IAYGPQGYFYKGWNQFDFFVVCASIVDIVMTFLGKSVIGFLRAGPQIIRILRVLRVSRLF
Tt8516          NLGFTGVFIAECWNQFDFFVVCASVVDIIMSYSGKSFFSFLKAGPQIARVLRVLRVSRLL
Tt11012         IAYGFNGYFYKSSNQFDFFVVSVSVIDIIFTYSGNQFIKFLSAGPQIARIFRVFRVTRLL
Tt27559         LQTQITGHGYSQKRDIKDRKSKLQLFSKRKIFQELINFNVRLYSNDKTHFMDFCVKISRN
Tt14193         LQLPLYTHTNKEGKSYFGFRFHDVVIQMTQVSLFLRFGILPGGPQ--EDPKRIEQFYQEL
Tt27255         FCYKFHDVVISISKISVQIKYGITTLEPENSNLRNQLDSLIKKKKLSGDDMIKPTSFTSA
ScCCH1          MEVNPDDPYDVKIDLIGLNKELNTIDKAKIIQRKLQYRRFVQSIHYTNAYNGCIRFSDLL
20.m03897       AVLNSAKRACEFHAMSHGVMDMQDGQVELNPHLITSWIGKFPEVAHTTAEYDLRHYLAAE
583.m05406      AGSASAFHPSCTTETFDDLSRSLAFIRVLRGIRICFRISPLRKMIVSLVAAVAALKTVLL
Tg3277          QASGIFHLGRKVPHVEEEKKDERKVVACLNLANLHPLDILQHPAILDALEKAGIPLFQAF
                                                                            

HsCAC1B         MIFDFYKQNKTTRDQMQQAPGGLS--------------QMGPVSLFHPLKATLEQTQPAV
CeEGL19         LIQDYFRRFKKRKEMEAKG--------------------------VLPAQTPQAMALQAG
CeUNC2          LILENYRARKSGTEVGGQGLFG-----------------GGLRSLVAAAKAAESQHSSHT
DmCA1A          LILESWR--------STRFGQL----------------DSG-MPMLELQDASRHPSQESL
DmCA1D          LIQDYFRRFKKRKEQEGKEGHP----------------DSN-TVTLQAGLRTLHEVSPAL
MmCACNA1D       LIQDYFRKFKKRKEQGLVGKYP----------------AKNTTIALQAGLRTLHDIGPEI
RnCAC1B         MIFDFYKQNKTTRDQTHQAPGGLS--------------QMGPVSLFHPLKATLEQTQPAV
MmCACNA1A       MIMEYYRQSKAKKLQAMREEQNRT--------------PLMFQRMEPPSPTQEGGPSQNA
CeCCA1          ELIEVERHLEER---YRRAS--------------------------ECLGGELQPLNPGE
MmCACNA1H       SPRDTPRSLSLSRILYRQEAMH-----------------------AESLEGQIDDAGEDG
CeNCA1          WLEGCLRKMRNPSQKDAEGVLP--------------------FGGGHPVIHSSGHSS---
RnRB21          WLKKCLKRIRAKQQQSCS------------------------------IIHSLRE-----
CeNCA2          WLENCLKNIKAKQNNTLG------------------------------KMSSIGS-----
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         KLVKSMKGLQKLIETLMFSLPSLINVGALLLLVFFIYSILGVFMFKDVTEGVVIDKYNNF
Tt8511          KLIKSFQNLQKLIQTTIFALPHLLNATALFLLFYFIFAILGCYLFSSVTEGNVIDQFNNF
Tt8517          KLMKSFQGLMKLIQTTIFAFPKFLNATLLFVLFYFIFSILAWYLFSDLRSGWRINTFWNF
Tt8516          KLIKSFQGLQKLIQTTVFAFPKFLNATLLFVLFYFIFSILAWFLFSDLQSGWRLSTFWNF
Tt11012         RLIKQFEGLQKLMSTLIYALPSLTNATALLFLIYFIFAILACYLYSPYQMSTGEDWYLIM
Tt27559         AIMKKAKDNNISDPFLINSR----------------------------------------
Tt14193         DQKNKFVAHKSHLKSGDIAVIVIIQR----------------------------------
Tt27255         DMVLIIVLTRKVKQWRQKVLGKQE------------------------------------
ScCCH1          LQIPLYTAYSARECLGIDQYVHHLYILG--------------------------------
20.m03897       TIQNWFRKRHMVINGELANPEWCAAR-------------VVSFLVEAQTARLHRPSGRNV
583.m05406      VLVVIFCAYGTVGMELFGG-----------------------------------------
Tg3277          DVLNLYYTRGVEFITVKEFAESCG------------------------------------
                                                                            

HsCAC1B         LRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGH-----
CeEGL19         LR----------------------------------------TLHEIGPELKR-------
CeUNC2          PQ----------------------------------------PPEETTPIIPQHA-----
DmCA1A          TGADAG------------------------------------HLHPGHSYMNG-------
DmCA1D          KRAISGNL--------------------------DELDQEPEPMHRRHHTLFG-------
MmCACNA1D       RRAISCDLQ---------------------DDEPEDSKPEEEDVFKRNGALLGNHVNHVN
RnCAC1B         LRGARVFLRQKSATSLSNGGAIQTQESGIKESLSWGTQRTQDVLYEARAPLERGH-----
MmCACNA1A       LPSTQLDPG--------------------------------GGLMAHEGGMKESP-----
CeCCA1          IEDLDD------------------------------------------------------
MmCACNA1H       IPDYTEPAE---------------------------------NISMSQAPLGTLR-----
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ENFGNAMITLFRCSTGENWYQFMFDCGKTSGCVQGKDCGSHYHMKEDNPLQAFNDKLNIF
Tt8511          KDFHSAFILLFRCSTGEDWMTVMFDIVKGTSNYSIIYFVVFIIIQTYMMMNLFVLIIINQ
Tt8517          SNFHRAFILLFRMSTGEDWYLVMYDTFNAKGVYGILFFVTFYTVQSYILMNLFVLIIMNE
Tt8516          TNFHRAIILLVRMSTGEDWYLVMYDTFNAKGVIGLIFFVSFYTVQSYILMNLFVLIIMNE
Tt11012         FDIIHHTN-----------------------MWSAFFFVVFIIIQQYIMMSLFILIIIEQ
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       LRG---------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         -----STEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTD
CeEGL19         -----------AISGNLETDFNFD---------EPEP-----------------------
CeUNC2          -----QQFSAAPTMSAQGSLQQMQG-TSSGGGQRPYSLFNSFVDTIKSGKQDGDVTDVQY
DmCA1A          -----HRRSPSLRHNGSPLARSPSPRRR---------GHQYIHHDIGFSDTVSNVVEMVK
DmCA1D          -----SVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAG
MmCACNA1D       SDRRDSLQQTNTTHRPLHVQRPSMPPASDTEKPLFPPAGNSGCHNHHNHNSIGKQAPTST
RnCAC1B         -----SAEIPVGQPGALAVDVQMQNMTLRGPDGEPQPGLESQGRAASMPRLAAETQPAPN
MmCACNA1A       ---------SWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSE
CeCCA1          ---------PEFRPRSRSHRPRARTNSALSNKSR-----GSHKSAL--------------
MmCACNA1H       --------SPPCSPRPASVRTRKHTFGQHCISSRPPTLGGDDAEAADPADEEVSHITSSA
CeNCA1          ----------ISHEETVAQRLRFENIRGDSVDTEETESSEEETP--PPIRKKAAVKNRRG
RnRB21          -----------SQQQELSRFLNPPSIETTQPSEDTNANSQDHNT--QPE----SSSQQQL
CeNCA2          -----------TFAFPQSQEVLTKGVVLTEASPEEDSLQGDKGSGKK-------KAQRGN
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         RITWSKYTKKTLGEKINSKDIVDFLYELPLPLGIIILNKRVKILLNELNIKGYHDPDPNA
Tt8511          FEENYIDPDNPLQNFTESEDNFKQLWGIMTEKDQGIKIHERFLTDFYFQLQEPLGYDYNM
Tt8517          FEENYINPDNPLNNFNEQEDDFKKRWVIMTIKDSGIKIHEKNIPDFYFELQEPLGFDYKR
Tt8516          FEENYINPDNPLSNFNEQEEQFKKRWVQMTQKDSGIKIHEKYLTEFYFELPAPLGFDFLR
Tt11012         FENNYINPDNPINDFQYSEEDFKKQWVQFTRNSYGIKIHERFITDFYFSILRPLGFDYKS
Tt27559         ---------IVIEDSLVQTLMKNWETEYPTLKKYNKRKDEFNQPKKYFTILNYYAAVTIQ
Tt14193         -----------RIKNWMERGKHLYKIKKENPAQYAEKLNEYHQSYRSLNINSIIKISQKD
Tt27255         -------EYILDIKQLTQKLKSQFNKSQNINLEQAQKEEENDKKQTNQEIQQLNQQQTTE
ScCCH1          ----------KVDKYLENQRNFDVLEMVVTRWKFHCRMKRTIEPEWDVKDPTVSSHISNI
20.m03897       ---------SLLDHRQSTSGKRRSQPGSQTDSTTGSSRLVTISSGESYETLCASEEPTPM
583.m05406      -----------IIKCDMEHLPPKGPDMEDPTDWGVLNFNDFFASLVTLFLLTVNGWDDSL
Tg3277          ---------RVCGTSTGRQLLQMQIDLHQKLNRVEKRVRRLTRALVQQQQLVLLQQQQLL
                                                                            

HsCAC1B         ASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLS
CeEGL19         ------------QHRRPHSLFNNLVHRLSGAGSKSPTEHERIEKG-STLLPFQPRSFSPT
CeUNC2          QSVDQQHEKMNSTGRRLSDMFSKIRRGTSADHNPHQTEHLLAQDNRSPSSP-RYRSMARA
DmCA1A          ETRHPRHGNSHPRYPRGSWSASTSPARSP--SPSRYGGHLS---RSKRTQLPYPTYGTTS
DmCA1D          GDYLYDTLNRSVADGVNNITRNIMQARLA--AAGKLQDELQGAGSGGELRTFGESISMRP
MmCACNA1D       NANLNNANMSKAAHGKPPSIGNLEHVSENGHYSCKHDRELQRRSSIKRTRYYETYIRSES
RnCAC1B         ASPMKRSISTLAPRPHGTQLCNTVLDRPPPSQVSHHHHHRCHRRRDKKQRSLEKGP-SLS
MmCACNA1A       HYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLSTISDTSPMKRSASVLGPKARRLDDYS
CeCCA1          ------------------------------------------------------------
MmCACNA1H       HPWPATEPHSPEASPTASPAKGTVGSGRDPHRFCSVDAQSFLDKPGRPDAQRWSSVELDN
CeNCA1          SIPDVLSRTGLFQEAARKFMVGSSSEKKQVKSRSPETVQLLPKRANSEIRKGSGQPKNFH
RnRB21          LSPTLSDRGGSRQDAADT----GKPQRKIGQWRLPSAPKPISHSVSSVNLRFGGRTTMKS
CeNCA2          SITEIVAEAQKKSVKRAT----DKISERRGTLRQMQMGTYDELEEVEEDEDTDGEIRRSS
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ATAHPVAKKEIARQVMNWALVQQMGEQKFYFQQTKFTIYLFKIKRDQQEYVFFNDMLFAC
Tt8511          KKKTFIENLKLHNSGISDEEIKSKCEKFKIKQRQEADKHIMQMNIYCDYEGYIFFNELFF
Tt8517          KSNEFVEKLKMHDTEITQDEINLKLDKYKIRQKQEADKNVMRMNIFCDYEGYVYYNELLY
Tt8516          KSEDFVDQIKSRDNSITHEEIQSRLDRFRIRQRQEADKNIMKMNVFCDYEGYIYFNDLFY
Tt11012         KLKEFVEQVKTINQQVSEQDLELITGKFRIKQKQLAEKEIMKMNIRCDYDGYIFYNELLY
Tt27559         DYIRQVQREKKIKEQIIKNKLSSKMNKTENINTYSLTNNQKQKVLQRNYTNKPWSSNNKK
Tt14193         QEEDAQSIIKPHGKKQIFSNFSNIATARQTGEKSSEGESSQQDSDKQNESEGSSHFSEKQ
Tt27255         QLKIKDILKEDKQQDTEQFIPITVKSKLPPIEKKKFNSKQSTLNKAEKNVKFIECLQTKP
ScCCH1          NVNLEPAPGILEREPIATPRMDYGVNNFMWSPRMNQDSTMEPPEEPIDNNDDSANDLIDR
20.m03897       TGGINQARMSLTEPTSARGSASGSSSNSRRGSLRPGNDLDLAPRVLFESCLLVPEGESTK
583.m05406      KALVKHTSVFSCGAYFVSFYILTDTIILNLLVALVLEAYDQVASSSSSSWRPVL------
Tg3277          SAITRSRSIWGWSDKERKTDFVDISRRWHSYKPPKSSWEEFWEFFALVQDSSRL------
                                                                            

HsCAC1B         ---------------------------------ADMDGAPSSAVGPGLPPGEGPTGCRRE
CeEGL19         ---------------------------------HSLAGAEGSPVPSQMHRG-APIN----
CeUNC2          ---------------------------------SPPSPAERYGHPPRYRTESPPSSRSEY
DmCA1A          -------LCQRS---------------------RSPSPARLQEMRERDRLGYGIDMG---
DmCA1D          -------LAKNG---------------------GGAATVAGTLPPEANAINYDNRNRGI-
MmCACNA1D       GDEQFPTICREDPEIH-GY-FRDPRCLGEQEYFSSEECCGDDSSPTWSRQNYNYYNRYPG
RnCAC1B         ---------------------------------VDTEGAPSTAAGSGLPHGEGSTGCRRE
MmCACNA1A       ---------------------------------LERVPPEENQRYHQRRRDRGHRTSERS
CeCCA1          ------------------------------------------------------------
MmCACNA1H       GD-------------------------------GHLESGEVRARASELEPALGARRKKKM
CeNCA1          ------------------------------------LQLNVYDLPDVEERGEDSPFSPKN
RnRB21          ------------------------------------VVCKMNPMPDTASCG---------
CeNCA2          ------------------------------------FEYSGVDMIQ--------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         MKKEYGSKLMQNAGPE-LM-KMLNKLEVETRLKIAEKKKKQILKKNKKVFGGHHQKGQKK
Tt8511          YFFKFSLKDEVNDFPQ-PKNQKELEKQIKALQIMRKEESITFKRMNYIKKKQSQLIKQKI
Tt8517          QFMKFS---------------------------LYEQVYELSIEDQNDPKLQSSLLKSKI
Tt8516          QLFKFS---------------------------LYSSVYELDVNSQEDPKALQRHNTALE
Tt11012         YFFKHSLYDSVFGRIDNASTKSEYEKCIKAEEILYKEEHITRRKLRILKKKQAALTKQKF
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       -----------------------------------QPSSKERLSVSSMRAGDGLLSATPG
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         R----------ERRQERGRSQERRQPSSSS-SEKQRFYSCDRFGGREPPKPKPSLSSHPT
CeEGL19         --------------------QSINLPPVNG-SARR----------------LPALPPYAN
CeUNC2          Q----------MSIRDPIIRRNRYNTMEHSRSSHDPQYHQDQQQQQQPHHQQHSQHLQHS
DmCA1A          ----------------VTHVQHSYPTLASRRAGIGRRLPPTPS----KPSTLQLKPTNIN
DmCA1D          ----------------LLHPYNNVYAPNGALPGHERMIQSTPA----SPYDQRRLPTSSD
MmCACNA1D       SSMDFERPRGYHHPQGFLEDDDSPTGYDSRRSPRRRLLPPTPPSHRRSSFNFECLRRQSS
RnCAC1B         R-------------KQERGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQPKPSLSSHPI
MmCACNA1A       LG-------RYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHH
CeCCA1          ------------------------------------------------------------
MmCACNA1H       SP---------------PCISIDPPTEDEGSSRPPAAEGGNTTLRRRTPSCEAALHRDCP
CeNCA1          LS------------------------DDFNGEHSPLVITPSLPVPPTHGSPRPLMPCETT
RnRB21          ------------------------------------------------SEVKKWWTRQLT
CeNCA2          ------------------------------------------------------MSHEKQ
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ANPMIAFMFLQMSFKAWQNYSVEKTAKGIVDGQQEEKSSSSSSEESFSSEEEEELNNEEI
Tt8511          NKKRKEGVNPMVRRLFVGMCFQSWIQYSKSTQKKINDLNFNHEDISSQSETDSDSENEED
Tt8517          VHQRQQGVNPMVRRLFVGMAFKSWLQYSIKMQDNMNQINFNREDISSQTDTDNSQDEDLE
Tt8516          ILKKEEKVTWKKIGIIKKKAKIVLQRQQGVNPMVRRLFVGMAFKSWLQYSIRTQDNLNQI
Tt11012         ISSRQKEVNPMVRRLFVGMCFKSWLKYSQKIQNNIMQDYDDISSQTDSDEEYDQLQVDPE
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------QDTEDGLVLQNN
ScCCH1          ------------------------------------------------------------
20.m03897       EN-------------------ILERRLGPSRPARLADGEGEVRERSNRPKIRRSFIRDGQ
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ------------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          ------------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          ------------------------------------------------------------
MmCACNA1D       ------------------------------------------------------------
RnCAC1B         ------------------------------------------------------------
MmCACNA1A       ------------------------------------------------------------
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ------------------------------------------------------------
Tt8511          ------------------------------------------------------------
Tt8517          ------------------------------------------------------------
Tt8516          ------------------------------------------------------------
Tt11012         DLQNALAIDKFYTSQDKEENIIEVLKNRRFIIPRLHTIKLRKQDQKEQIADGFFNGKYFE
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       ------------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ------------------------------------SPTAGQEPGPHPQGSGS-VNGSPL
CeEGL19         ------------------------------------HIHDETDDGPRYRDTG--------
CeUNC2          ------------------------------------HHKTYQNHNQYSRSPIY-SDDSSV
DmCA1A          ------------------------------------FPKLNASPT----------HTHHS
DmCA1D          ------------------------------------MNGLAESLIGGVLAAEGLGKYCDS
MmCACNA1D       ------------------------------------QDDVLPSPALPHRAALP-LHLMQQ
RnCAC1B         ------------------------------------SPTAALEPGPHPQGSGS-VNGSPL
MmCACNA1A       ------------------------------------PPAPDRDRYAQERPDTGRARAREQ
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------ESTEGPGTGGDPVAKGE-------
CeNCA1          ------------------------------------KDIEKWWNSLVD------------
RnRB21          ------------------------------------VESDESGDDLLDI-----------
CeNCA2          ------------------------------------LEDVKTWWTLCD------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ------------------------------------QNNEEDQNNKQDINNGEIEKQSVQ
Tt8511          ------------------------------------EIDFLKNDEKDVLQFRQNFKKKII
Tt8517          ------------------------------------NEEEENLFLNQSFEDG--------
Tt8516          ------------------------------------NFNKDDISSQTDSENSQDENNEQI
Tt11012         FPNPDEIYKAELENEQNINEFEERINEQQKQLQIIKNNEQNNKQMLSSVNSNYQERTKSI
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       ------------------------------------KRSTAELRVSGDTQRRNSFHECEI
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         LSTSGASTPGRGGRRQLPQTPLTPRPSITYKT-------ANSSPIHFAGAQTSLPAFSPG
CeEGL19         ---------DRAGYDQSSRMVVANR--------------------KYADARIVGAARREI
CeUNC2          AESYRREREFRRYQDSTPQDVSEDDDPMPTAVRARRLPLISTMPTHYESAYQPSSYNQHL
DmCA1A          TPHSVHSLPHHRDLLRDPRDMY------------------YSSRERERDRERLRDRDRDR
DmCA1D          EFVGTAAREMREALDMTPEEMN------------------LAAHQILSNEHSLSLIGSSN
MmCACNA1D       QIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWSPCYTPLIQVDRSESMDQVNGSL
RnCAC1B         MSTSGASTPGRGGRRQLPQTPLTPRPSITYKT-------ANSSPVHFAEGQSGLPAFSPG
MmCACNA1A       RWSRSPSEGREHTTHRQGSSSVSGSPAPSTSG--------TSTPRRGRRQLPQTPCTPRP
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ----------------------------------------RWGQASCRAEHLTVPNFAFE
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         SASRKKSEFGLRDKFSRKGTYISKTNSQNKQDLKNDILNKNKHQQSSKLQLSSSSSSSQS
Tt8511          EREHTIFSRPVVKNEKNPNNLYEKERYVYLPNTEIYKDEYVIDDKDYYTKQVFQVESNQK
Tt8517          ---------------------------------------IQFKKQKPKIIKREHTVALRI
Tt8516          DNFYLDESFEDG---------------------------IQFKKQKPGIIKREHTITFRP
Tt11012         QRSQLNNQRNNTLKLSHAFNIPSKRTSIDNVQSNNQLVPKDQTKLKLSLVESSNSLGMSV
Tt27559         ------------------------------------------------------------
Tt14193         ----------------------------------------IQETPNLMSGLFESIQQHDF
Tt27255         ---------------------------------------NQDDFNYNNIEQPNKITDQQF
ScCCH1          ------------------------------------------------------------
20.m03897       GIQTHNETTDQHCLIERGTHLDHGR---------------QGVASNCAVTVTTPPSQMQA
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         RLSRGLSEHNALLQRDPLSQPLAPGSRIGSDP--YLGQRLDSEASVHALPEDTLTFEEAV
CeEGL19         EEAYSLGEQ----EIDLAADSLAP---------------LMQHVGMHDIRDINENSRSAL
CeUNC2          NDSYGLGTGYQRDYHTSHSHSHHPTSQQQQHQPMYSTSPLISPRSSHSYYTPRSSQYYEI
DmCA1A          D------------------------------RDRLHEYDLRYEYRDRERELYERE---RD
DmCA1D          GSIFGGSAGGLG---GAGSGGVGGLGGSSSIRNAFGGSGSGPSSLSPQHQPYSGT---LN
MmCACNA1D       PSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYAR
RnCAC1B         RLSRGLSEHNALLQKEPLSQPLASGSRIGSDP--YLGQRLDSEASAHNLPEDTLTFEEAV
MmCACNA1A       LVSYSPAPRRPAARRMAGPAAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPREP
CeCCA1          ------------------------------------------------------------
MmCACNA1H       PLDMGGPGGDCFLDSDQSVTPEPRVSSLGAIVPLILETELSMPSGDPPEKEQGLYLTVPQ
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         SNSESNSSSDDSSSSSSSQSRPNSKEKKSQTHSKIFDKQFSKKGNKSIVFDQISEKEDKE
Tt8511          KQQYSTQDSKPFSETKIQRELLKSPTNQSIDTPVNFQVNSNQNMYSQSSSQQKLSKFNNQ
Tt8517          DGLRKYREEQNTGKQIYQGKKYFYIPDTNIYQIDNYDEYNNQDYNSHTFQVEQKQDLQVE
Tt8516          GGLKKYRDEHEKQQQIKQNKKYHRLPNVDVYQQDCYDEKNAKYFEVDEDDVYVETKHYIQ
Tt11012         RKESIVKKDSHNVSTPKSQLNLSQVKKLTLQKNNSNSPRLQVPLENNRQRKDSKSIFSMT
Tt27559         ------------------------------------------------------------
Tt14193         NKIYSNKFESISLKQKNIESSYKNFANVQNVKDSNINIINYYNITNNYYNSNFNLQKSSQ
Tt27255         EKNKSLPVKISKQNSNASNNISNTQIQQKSSSEQNQNQNIQSPENNNNCQENQEKQFRDE
ScCCH1          ------------------------------------------------------------
20.m03897       SEGEDAPRRSLRHHHTRTTSEAYTHGNSRDPQTGEASPFTNMADTYKRYTRTAVTQRRLP
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         ATNSGRSSRTSYVSSLTSQSHPLRRVPNG------YHCTLGLSSGGRARHSYHHPDQDHW
CeEGL19         LRPAENSSRQHDSRGGSQEDLLLVTTL---------------------------------
CeUNC2          PSPS-PDIYPSYRGSASPRRYPTSTVVVAPDREGSSARVIQAQPGSIPLSDSETEDDPRW
DmCA1A          REREVERERLEYIAPLSFEQALAMGRTGRVLPSPVLNGFKPKSGLNPRHSDSDEEDWC--
DmCA1D          SP-PIPDNRLRRVATVTTTNNNNKSQVSQNNSNSLNVRANANSQMNMSPTGQPVQQQSPL
MmCACNA1D       DPKFVSATKHEIADACDLTIDEMESAASTLLNGSVCPRANGDMGPISHRQDYELQDFGPG
RnCAC1B         ATNSGRSSRTSYVSSLTSQSHPLRRVPNG------YHCTLGLSTGVRARHSYHHPDQDHW
MmCACNA1A       PGGAHDPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESEDDW
CeCCA1          ------------------------------------------------------------
MmCACNA1H       TPLKKPGSPPATPAPDDSGDEPV-------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         EQSPNQKRNQDSRKLRRIDTLNLKKLDTEFEFGQTNKYQYSANQNQNKLVNANKVQFSKQ
Tt8511          QINQEDEQEEKQIILESQDPQPIQLKIPSINVLSSCKDLSDEQQAYKGNDIQSLNTIQNM
Tt8517          NNQLYRKSIFDRPSLRMANPLQFRQSIASLQQDDSNEKNGSQQNLTPGYHSKEKQK----
Tt8516          EETGRKSILQRPSILFANPLQPRKSVLHTLVSEKDNSDVRKSINQKYQNIMKENAILESD
Tt11012         PQNRANENENIEDKLNSQHLMHLQATPITFTQFVNSKNFMSSPENESDDEHKQQIRLDLT
Tt27559         ------------------------------------------------------------
Tt14193         SSQGQLDSLSSRPIKQTEQIDIPSEKIKKL------------------------------
Tt27255         KLKFSILPIEFKATSVIQEQDNYQDDDFGLDVNFNQNFIFAFDEQEETQNI---------
ScCCH1          ------------------------------------------------------------
20.m03897       SPLTAVSDEVFRESPGSKHEHKKTPQRHTHCNRGAEEGLESSLPNFISDGESSDEKEKVT
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         C-----------------------------------------------------------
CeEGL19         ------------------------------------------------------------
CeUNC2          AIV---------------------------------------------------------
DmCA1A          ------------------------------------------------------------
DmCA1D          RGQGNQTYSS--------------------------------------------------
MmCACNA1D       YSDEEPDPGREEEDLADEMICITTL-----------------------------------
RnCAC1B         C-----------------------------------------------------------
MmCACNA1A       C-----------------------------------------------------------
CeCCA1          ------------------------------------------------------------
MmCACNA1H       ------------------------------------------------------------
CeNCA1          ------------------------------------------------------------
RnRB21          ------------------------------------------------------------
CeNCA2          ------------------------------------------------------------
NtTPC1A         ------------------------------------------------------------
AtTPC1          ------------------------------------------------------------
OsTPC1          ------------------------------------------------------------
CfTPCN2         ------------------------------------------------------------
HsTPCN2         ------------------------------------------------------------
Tt10302         ANTSIEMLSKNSIFNLKNKPTDQNKLQKQTSLKNYF------------------------
Tt8511          PSSGTNFIEKEEMPLTLQTKQVDIVSKFKNQYK---------------------------
Tt8517          ------------------------------------------------------------
Tt8516          NEQK--------------------------------------------------------
Tt11012         KQQSSQIKSPKKEISRFGESSSIINQLKQDFNINGHEKNNESNDKHSSIMNMPNLQQKSY
Tt27559         ------------------------------------------------------------
Tt14193         ------------------------------------------------------------
Tt27255         ------------------------------------------------------------
ScCCH1          ------------------------------------------------------------
20.m03897       RWFA--------------------------------------------------------
583.m05406      ------------------------------------------------------------
Tg3277          ------------------------------------------------------------
                                                                            

HsCAC1B         -------------------------------------
CeEGL19         -------------------------------------
CeUNC2          -------------------------------------
DmCA1A          -------------------------------------
DmCA1D          -------------------------------------
MmCACNA1D       -------------------------------------
RnCAC1B         -------------------------------------
MmCACNA1A       -------------------------------------
CeCCA1          -------------------------------------
MmCACNA1H       -------------------------------------
CeNCA1          -------------------------------------
RnRB21          -------------------------------------
CeNCA2          -------------------------------------
NtTPC1A         -------------------------------------
AtTPC1          -------------------------------------
OsTPC1          -------------------------------------
CfTPCN2         -------------------------------------
HsTPCN2         -------------------------------------
Tt10302         -------------------------------------
Tt8511          -------------------------------------
Tt8517          -------------------------------------
Tt8516          -------------------------------------
Tt11012         SQQSDKHQAKIPIDNQEHKKPNLNKNIPQIRINFEED
Tt27559         -------------------------------------
Tt14193         -------------------------------------
Tt27255         -------------------------------------
ScCCH1          -------------------------------------
20.m03897       -------------------------------------
583.m05406      -------------------------------------
Tg3277          -------------------------------------